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• W2081939076 abstract "Background: Dopamine is reported to be a coronary vasodilator; however, the exact mechanism of dopamine action in the coronary circulation remains unclear. In this study, we hypothesized that dopamine-induced activation of coronary ATP-sensitive potassium (KATP) channels may be associated with coronary vasodilation. We therefore investigated the direct effects of dopamine on coronary KATP-channel activity. Methods: We used patch-clamp configurations to investigate the effects of dopamine on coronary KATP-channel activity. Results: Application of dopamine (10−9 to 10−5 M) to the bath solution during cell-attached recordings induced a concentration-dependent increase in KATP-channel activity. In contrast, dopamine failed to activate KATP channels in inside-out patches. Dopamine-induced coronary KATP-channel currents in cell-attached patches were inhibited by pretreatment with the selective D1-like antagonist, Sch-23390, but they were not influenced by the selective D2-like antagonist, domperidone, or the β-adrenergic receptor antagonist, propranolol. The selective D1-like agonist, SKF-38393, and the adenylyl cyclase activator, forskolin, mimicked the dopamine effects on coronary KATP channels. Furthermore, pretreatment with an inhibitor of protein kinase A, Rp-cAMPS, abolished the dopamine-induced KATP-channel activation. Conclusions: This study demonstrates that dopamine activates coronary KATP channels via signal transduction involving the D1-like dopaminergic receptor-protein kinase A-signaling pathway." @default.
• W2081939076 created "2016-06-24" @default.
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• W2081939076 date "2008-02-01" @default.
• W2081939076 modified "2023-10-15" @default.
• W2081939076 title "Effects of Dopamine on ATP-Sensitive Potassium Channels in Porcine Coronary Artery Smooth-Muscle Cells" @default.
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• W2081939076 doi "https://doi.org/10.1097/fjc.0b013e31815f2be7" @default.
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