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- W2081959084 abstract "Abstract The interrelation between tumor growth, the anterior pituitary, and the adrenal glands is discussed. The histologic changes in the adrenals of chickens, rats, and mice, bearing tumor, have been studied. The weight of adrenal glands is increased in cancerous animals, particularly in chickens with Rous sarcoma. Two stages of cellular reaction have been found in the adrenal cortex, hyperactivity of the zona reticularis, in incipient malignancy, and lipoid accumulation and fatty degeneration of the cortical part, similar to b -avitaminosis in large tumors. These two stages probably correspond to two different stages of glandular activity: hyperactivity of the adrenal cortex in the beginning of malignancy and hypofunction with the progress of tumor growth. Unilateral adrenalectomy seems to have no effect on the growth of transplanted tumor. Bilateral adrenalectomy has a definite inhibiting effect upon it. Grafting of adrenal tissue does not produce any noticeable effect on tumor growth. The regenerative power of the cortical tissue is more pronounced in grafts in rats with large tumors than in non-cancerous rats. This suggests that the organism affected by cancer must have some physiologic need for the biologic principle elaborated by the adrenal gland." @default.
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- W2081959084 date "1940-09-01" @default.
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- W2081959084 title "Adrenal glands and malignancy" @default.
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- W2081959084 doi "https://doi.org/10.1016/s0002-9610(40)90585-2" @default.
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