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- W2081966146 abstract "The response of single, motion-sensitive neurons in the vestibular nuclei to systemic administration of perphenazine was studied in 18 cats. 14 of the 22 units examined showed depression of their activity. The extent of depression for a given dose varied from one neuron to another; it was independent of specific type of motion sensitivity and whether the animal was in motion or at rest. The other units tested, approximately one-third of the total, showed either an excitatory response, a biphasic depression-excitation or no response at all. These results suggest that the drug effect was not a simple, direct one. Since perphenazine is known to act on ascending systems of the brainstem reticular formation, presumably via adrenergic blockade, the interpretation is offered that response of the vestibular neurons to the drug could have been mediated, in part, through the reticular formation." @default.
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- W2081966146 date "1972-08-01" @default.
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- W2081966146 title "Perphenazine action on vestibular neurons" @default.
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- W2081966146 doi "https://doi.org/10.1016/0014-2999(72)90005-2" @default.
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