FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081979449> ?p ?o ?g. }

• W2081979449 endingPage "4522" @default.
• W2081979449 startingPage "4513" @default.
• W2081979449 abstract "The PR264/SC35 splicing factor belongs to the family of SR proteins which function as essential and alternative splicing factors. Here, we report that the human PR264/SC35 locus is bidirectionally transcribed. Double in situ hybridization experiments have allowed simultaneous detection of sense and antisense RNA in human CCRF-CEM cells, suggesting that expression of the corresponding genes is not mutually exclusive. We have characterized three main classes of ET RNAs encoded by the opposite strand of the PR264/SC35 gene and containing PR264/SC35-overlapping sequences, PR264/SC35-non overlapping sequences or a combination of both. We show that their expression results from the use of alternative promoters, exons and polyadenylation signals. PR264/SC35-non overlapping ET mRNA species potentially encode two protein isoforms (449 and 397 amino acids) and are expressed from the PR264/SC35 promoting region. Northern blots and RNase protection analyses indicate that ET polyadenylated RNAs are differentially expressed in several human cell lines. Similar studies performed in the mouse have revealed that the bidirectional transcription of the PR264/SC35 locus is a conserved mechanism and that the open reading frame identified in a subset of human ET mRNAs is highly conserved (93% homology). Northern blot analyses performed with several murine tissues confirmed the differential expression of the ET gene and revealed that it is predominantly expressed in the testis." @default.
• W2081979449 created "2016-06-24" @default.
• W2081979449 creator A5063898371 @default.
• W2081979449 date "1997-11-15" @default.
• W2081979449 modified "2023-09-24" @default.
• W2081979449 title "Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene" @default.
• W2081979449 cites W1507502433 @default.
• W2081979449 cites W1532161523 @default.
• W2081979449 cites W1780179360 @default.
• W2081979449 cites W1799025295 @default.
• W2081979449 cites W1849644714 @default.
• W2081979449 cites W1872023405 @default.
• W2081979449 cites W1890830291 @default.
• W2081979449 cites W1967159817 @default.
• W2081979449 cites W1971956957 @default.
• W2081979449 cites W1974450466 @default.
• W2081979449 cites W1980458092 @default.
• W2081979449 cites W1987530472 @default.
• W2081979449 cites W1996063915 @default.
• W2081979449 cites W1999690952 @default.
• W2081979449 cites W2032057086 @default.
• W2081979449 cites W2032553250 @default.
• W2081979449 cites W2036045539 @default.
• W2081979449 cites W2036274952 @default.
• W2081979449 cites W2037005388 @default.
• W2081979449 cites W2041958161 @default.
• W2081979449 cites W2057051846 @default.
• W2081979449 cites W2063225252 @default.
• W2081979449 cites W2068411631 @default.
• W2081979449 cites W2074351361 @default.
• W2081979449 cites W2082491111 @default.
• W2081979449 cites W2084245305 @default.
• W2081979449 cites W2087492550 @default.
• W2081979449 cites W2098026512 @default.
• W2081979449 cites W2098441853 @default.
• W2081979449 cites W2100204438 @default.
• W2081979449 cites W2102694800 @default.
• W2081979449 cites W2133794546 @default.
• W2081979449 cites W2142122497 @default.
• W2081979449 cites W2145417552 @default.
• W2081979449 cites W2151784213 @default.
• W2081979449 cites W2157595631 @default.
• W2081979449 cites W2339203199 @default.
• W2081979449 cites W2407650738 @default.
• W2081979449 cites W2410945564 @default.
• W2081979449 cites W2411344999 @default.
• W2081979449 cites W78499632 @default.
• W2081979449 cites W2408839200 @default.
• W2081979449 doi "https://doi.org/10.1093/nar/25.22.4513" @default.
• W2081979449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147067" @default.
• W2081979449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9358160" @default.
• W2081979449 hasPublicationYear "1997" @default.
• W2081979449 type Work @default.
• W2081979449 sameAs 2081979449 @default.
• W2081979449 citedByCount "29" @default.
• W2081979449 countsByYear W20819794492014 @default.
• W2081979449 countsByYear W20819794492020 @default.
• W2081979449 crossrefType "journal-article" @default.
• W2081979449 hasAuthorship W2081979449A5063898371 @default.
• W2081979449 hasBestOaLocation W20819794491 @default.
• W2081979449 hasConcept C104317684 @default.
• W2081979449 hasConcept C142575336 @default.
• W2081979449 hasConcept C150194340 @default.
• W2081979449 hasConcept C153911025 @default.
• W2081979449 hasConcept C194583182 @default.
• W2081979449 hasConcept C36823959 @default.
• W2081979449 hasConcept C54355233 @default.
• W2081979449 hasConcept C54458228 @default.
• W2081979449 hasConcept C67705224 @default.
• W2081979449 hasConcept C86803240 @default.
• W2081979449 hasConceptScore W2081979449C104317684 @default.
• W2081979449 hasConceptScore W2081979449C142575336 @default.
• W2081979449 hasConceptScore W2081979449C150194340 @default.
• W2081979449 hasConceptScore W2081979449C153911025 @default.
• W2081979449 hasConceptScore W2081979449C194583182 @default.
• W2081979449 hasConceptScore W2081979449C36823959 @default.
• W2081979449 hasConceptScore W2081979449C54355233 @default.
• W2081979449 hasConceptScore W2081979449C54458228 @default.
• W2081979449 hasConceptScore W2081979449C67705224 @default.
• W2081979449 hasConceptScore W2081979449C86803240 @default.
• W2081979449 hasIssue "22" @default.
• W2081979449 hasLocation W20819794491 @default.
• W2081979449 hasLocation W20819794492 @default.
• W2081979449 hasLocation W20819794493 @default.
• W2081979449 hasLocation W20819794494 @default.
• W2081979449 hasLocation W20819794495 @default.
• W2081979449 hasLocation W20819794496 @default.
• W2081979449 hasOpenAccess W2081979449 @default.
• W2081979449 hasPrimaryLocation W20819794491 @default.
• W2081979449 hasRelatedWork W1986814994 @default.
• W2081979449 hasRelatedWork W1992703908 @default.
• W2081979449 hasRelatedWork W2011398844 @default.
• W2081979449 hasRelatedWork W2060929294 @default.
• W2081979449 hasRelatedWork W2133932782 @default.
• W2081979449 hasRelatedWork W2139592023 @default.
• W2081979449 hasRelatedWork W2139939269 @default.
• W2081979449 hasRelatedWork W2513916811 @default.
• W2081979449 hasRelatedWork W2733300197 @default.

• next