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• W2081980411 abstract "Objective: To evaluate the effect of low–bias flow oscillation (LBFO) with partial liquid ventilation (PLV) on perfluorochemical evaporation, histopathology, and oxidative tissue damage in an animal model of acute lung injury. Design: Prospective, randomized animal study. Setting: Research laboratory of a health sciences university. Subjects: Twelve New Zealand White rabbits. Interventions: Juvenile rabbits were anesthetized, paralyzed, and ventilated through a tracheostomy with either high-frequency oscillatory ventilation or LBFO. Lung injury was induced by repeated saline lavage, after which perflubron was instilled through a side port of the endotracheal tube. Lateral fluoroscopic images were performed at baseline and at various postfill intervals of animals in the high-frequency oscillatory ventilation–PLV and LBFO-PLV groups. The images were digitalized for computer analysis of the Lung Lucency Index, a surrogate marker of perflubron evaporation. Histopathologic evaluation was performed using a lung-injury scoring system. Malondialdehyde was measured in lung homogenates to assess oxidative damage. Measurements and Main Results: There were no significant differences in gas exchange and ventilator settings between groups throughout the experiment. At 300 mins, the high-frequency oscillatory ventilation–PLV group had a significantly higher Lung Lucency Index compared with the LBFO-PLV group in both dependent and nondependent lung regions (a high Lung Lucency Index correlates with increased perflubron loss). Malondialdehyde measurements were not different between groups. Animals treated with LBFO-PLV had a lower histopathologic lung-injury score compared with high-frequency oscillatory ventilation–PLV. Conclusion: LBFO-PLV is a viable mode of ventilation in a model of acute lung injury and is associated with significant preservation of perflubron in comparison with high-frequency oscillatory ventilation–PLV. The lower evaporative losses during LBFO-PLV were associated with improved histology scores." @default.
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• W2081980411 date "2005-11-01" @default.
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• W2081980411 title "Effect of low???bias flow oscillation with partial liquid ventilation on fluoroscopic image analysis, gas exchange, and lung injury" @default.
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• W2081980411 doi "https://doi.org/10.1097/01.pcc.0000171156.17113.2d" @default.
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