FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081983059> ?p ?o ?g. }

• W2081983059 endingPage "519" @default.
• W2081983059 startingPage "512" @default.
• W2081983059 abstract "Overcoming the low oral bioavailability of many drugs due to their poor aqueous solubility is one of the major challenges in the pharmaceutical industry. The production of amorphous solid dispersions (ASDs) of these drugs using hydrophilic polymers may significantly improve their solubility. However, their storage stability and the stability of their supersaturated solutions in the gastrointestinal tract upon administration are unsolved problems. We have investigated the potential of a low viscosity grade of a cellulosic polymer, hydroxypropyl cellulose (HPC-SSL), and compared it with a commonly used vinyl polymer, polyvinylpyrrolidone vinyl acetate (PVP-VA), for stabilizing the ASDs of a poorly water soluble drug, felodipine. The ASDs were produced using hot melt mixing and stored under standard and accelerated stability conditions. The ASDs were characterized using differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy. Drug dissolution and partitioning rates were evaluated using single- and biphasic dissolution studies. The ASDs displayed superior drug dissolution and partitioning as compared to the pure crystalline drug, which might be attributed to the formation of a drug-polymer molecular dispersion, amorphous conversion of the drug, and drug-polymer hydrogen bonding interactions. Late phase separation and early re-crystallization occurred at lower and higher storage temperatures, respectively, for HPC-SSL ASDs, whereas early phase separation, even at low storage temperatures, was noted for PVP-VA ASDs. Consequently, the partitioning rates for ASDs dispersed in HPC-SSL were greater than those of PVP-VA at lower and room temperature storage, whereas the performance of both of the ASDs was similar when stored at higher temperatures." @default.
• W2081983059 created "2016-06-24" @default.
• W2081983059 creator A5019374090 @default.
• W2081983059 creator A5034274190 @default.
• W2081983059 creator A5071058652 @default.
• W2081983059 creator A5090787138 @default.
• W2081983059 date "2014-11-01" @default.
• W2081983059 modified "2023-09-25" @default.
• W2081983059 title "Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine" @default.
• W2081983059 cites W1584222277 @default.
• W2081983059 cites W1900239988 @default.
• W2081983059 cites W1964670071 @default.
• W2081983059 cites W1971847221 @default.
• W2081983059 cites W1982596268 @default.
• W2081983059 cites W1985589720 @default.
• W2081983059 cites W2008667086 @default.
• W2081983059 cites W2013841303 @default.
• W2081983059 cites W2013930909 @default.
• W2081983059 cites W2014956897 @default.
• W2081983059 cites W2033716514 @default.
• W2081983059 cites W2036889536 @default.
• W2081983059 cites W2052637252 @default.
• W2081983059 cites W2058334287 @default.
• W2081983059 cites W2063442812 @default.
• W2081983059 cites W2067777829 @default.
• W2081983059 cites W2077032048 @default.
• W2081983059 cites W2078814811 @default.
• W2081983059 cites W2081468924 @default.
• W2081983059 cites W2087739820 @default.
• W2081983059 cites W2094039623 @default.
• W2081983059 cites W2148031361 @default.
• W2081983059 cites W2330536366 @default.
• W2081983059 doi "https://doi.org/10.1016/j.carbpol.2014.06.039" @default.
• W2081983059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25129775" @default.
• W2081983059 hasPublicationYear "2014" @default.
• W2081983059 type Work @default.
• W2081983059 sameAs 2081983059 @default.
• W2081983059 citedByCount "43" @default.
• W2081983059 countsByYear W20819830592015 @default.
• W2081983059 countsByYear W20819830592016 @default.
• W2081983059 countsByYear W20819830592017 @default.
• W2081983059 countsByYear W20819830592018 @default.
• W2081983059 countsByYear W20819830592019 @default.
• W2081983059 countsByYear W20819830592020 @default.
• W2081983059 countsByYear W20819830592021 @default.
• W2081983059 countsByYear W20819830592022 @default.
• W2081983059 countsByYear W20819830592023 @default.
• W2081983059 crossrefType "journal-article" @default.
• W2081983059 hasAuthorship W2081983059A5019374090 @default.
• W2081983059 hasAuthorship W2081983059A5034274190 @default.
• W2081983059 hasAuthorship W2081983059A5071058652 @default.
• W2081983059 hasAuthorship W2081983059A5090787138 @default.
• W2081983059 hasConcept C110884469 @default.
• W2081983059 hasConcept C121332964 @default.
• W2081983059 hasConcept C127413603 @default.
• W2081983059 hasConcept C14029885 @default.
• W2081983059 hasConcept C155574463 @default.
• W2081983059 hasConcept C160892712 @default.
• W2081983059 hasConcept C178790620 @default.
• W2081983059 hasConcept C185592680 @default.
• W2081983059 hasConcept C192562407 @default.
• W2081983059 hasConcept C200447597 @default.
• W2081983059 hasConcept C203036418 @default.
• W2081983059 hasConcept C2779251873 @default.
• W2081983059 hasConcept C2779351475 @default.
• W2081983059 hasConcept C2781218482 @default.
• W2081983059 hasConcept C2781430271 @default.
• W2081983059 hasConcept C39519442 @default.
• W2081983059 hasConcept C42360764 @default.
• W2081983059 hasConcept C43617362 @default.
• W2081983059 hasConcept C521977710 @default.
• W2081983059 hasConcept C56052488 @default.
• W2081983059 hasConcept C88380143 @default.
• W2081983059 hasConcept C97355855 @default.
• W2081983059 hasConceptScore W2081983059C110884469 @default.
• W2081983059 hasConceptScore W2081983059C121332964 @default.
• W2081983059 hasConceptScore W2081983059C127413603 @default.
• W2081983059 hasConceptScore W2081983059C14029885 @default.
• W2081983059 hasConceptScore W2081983059C155574463 @default.
• W2081983059 hasConceptScore W2081983059C160892712 @default.
• W2081983059 hasConceptScore W2081983059C178790620 @default.
• W2081983059 hasConceptScore W2081983059C185592680 @default.
• W2081983059 hasConceptScore W2081983059C192562407 @default.
• W2081983059 hasConceptScore W2081983059C200447597 @default.
• W2081983059 hasConceptScore W2081983059C203036418 @default.
• W2081983059 hasConceptScore W2081983059C2779251873 @default.
• W2081983059 hasConceptScore W2081983059C2779351475 @default.
• W2081983059 hasConceptScore W2081983059C2781218482 @default.
• W2081983059 hasConceptScore W2081983059C2781430271 @default.
• W2081983059 hasConceptScore W2081983059C39519442 @default.
• W2081983059 hasConceptScore W2081983059C42360764 @default.
• W2081983059 hasConceptScore W2081983059C43617362 @default.
• W2081983059 hasConceptScore W2081983059C521977710 @default.
• W2081983059 hasConceptScore W2081983059C56052488 @default.
• W2081983059 hasConceptScore W2081983059C88380143 @default.
• W2081983059 hasConceptScore W2081983059C97355855 @default.
• W2081983059 hasLocation W20819830591 @default.
• W2081983059 hasLocation W20819830592 @default.

• next