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- W2081985867 abstract "Radix Salviae miltiorrhizae, a traditional Chinese medicine, is applied widely in the treatment of cardiovascular, cerebrovascular, pulmonary, and nephritic diseases. Salvianolic acids are the main active components of Radix S. miltiorrhizae and are mainly used in the preparation of tablets, dropping pills and injections in traditional Chinese pharmaceutics. The purpose of this study is to develop an optimized spray-drying process to produce salvianolic acids particles and evaluate the physicochemical properties and in vitro deposition of the particles for application in dry powder inhalation (DPI). The spray-drying process was optimized according to a central composite design, using yield, median diameter, and the overall desirability as the responses. The physicochemical properties analysis and aerosolization properties evaluation on the particles indicated that the process obtained from multiple response optimization was more suitable for preparing particles applied in DPI. Under the optimized process,..." @default.
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- W2081985867 date "2011-03-28" @default.
- W2081985867 modified "2023-09-23" @default.
- W2081985867 title "Multiple Response Optimization of Spray-Drying Process for the Preparation of Salvianolic Acids Microparticles and Evaluation for Potential Application in Dry Powder Inhalation" @default.
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- W2081985867 doi "https://doi.org/10.1080/07373937.2010.514691" @default.
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