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• W2081988868 abstract "<b>Background:</b> MRI findings influence the risk of patients with optic neuritis (ON) developing clinically definite (CD) multiple sclerosis (MS) but their influence on future disability is less clear. <b>Objective:</b> To investigate in patients with ON the influence of lesion number, location and activity, and non-lesion MRI measures obtained on early scans on disability. <b>Methods:</b> A total of 106 of 143 prospectively recruited patients with ON had reached a scheduled 5-year follow-up, of whom 100 were evaluated clinically. Lesion number, location, and activity measures were analyzed at baseline (within 3 months of onset) and lesion activity measures were studied at 3-month follow-up. Brain atrophy, magnetization transfer ratio, and spectroscopy measures were also analyzed. Ordinal logistic regression assessed the association between early MRI findings and subsequent disability. <b>Results:</b> At median 6 years follow-up, 48% had converted to CDMS and 52% remained with clinically isolated syndrome (median Expanded Disability Status Scale 2 and 1). In the final models, both the presence and the number of spinal cord lesions at baseline (odds ratios [OR] 3.30, 1.94) and new T2 lesions at follow-up (OR 7.12, 2.06) were significant independent predictors of higher disability. Disability was also predicted by the presence at baseline of gadolinium-enhancing lesions (OR 2.78) and number of infratentorial lesions (OR 1.82). Only spinal cord lesions predicted disability in patients converting to CDMS. <b>Conclusion:</b> Spinal cord, infratentorial, and gadolinium lesions within 3 months of optic neuritis onset and new T2 lesions after 3 months predicted disability after 6 years; only spinal cord lesions were predictive of disability in those developing clinically definite multiple sclerosis. <b>BPF</b> = brain parenchymal fraction; <b>CD</b> = clinically definite; <b>CI</b> = confidence interval; <b>CIS</b> = clinically isolated syndrome; <b>EDSS</b> = Expanded Disability Status Scale; <b>FOV</b> = field of view; <b>Gd</b> = gadolinium; <b>GM</b> = gray matter; <b>GMF</b> = gray matter parenchymal fraction; <b>IQR</b> = interquartile range; <b>LR</b> = likelihood ratio; <b>MS</b> = multiple sclerosis; <b>MTI</b> = magnetization transfer imaging; <b>MTR</b> = MT ratio; <b>NAGM</b> = normal-appearing gray matter; <b>NAWM</b> = normal-appearing white matter; <b>ON</b> = optic neuritis; <b>OR</b> = odds ratio; <b>PRESS</b> = point resolved spectroscopy; <b>RRMS</b> = relapsing remitting MS; <b>SPMS</b> = secondary progressive MS; <b>TE</b> = echo time; <b>TR</b> = repetition time; <b>WM</b> = white matter; <b>WMF</b> = white matter parenchymal fraction." @default.
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• W2081988868 date "2009-02-09" @default.
• W2081988868 modified "2023-10-15" @default.
• W2081988868 title "Early MRI in optic neuritis: The risk for disability" @default.
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• W2081988868 doi "https://doi.org/10.1212/01.wnl.0000341935.41852.82" @default.
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