Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082003682> ?p ?o ?g. }
- W2082003682 endingPage "68" @default.
- W2082003682 startingPage "62" @default.
- W2082003682 abstract "Tobacco smoke and air pollutants contain carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and tobacco specific nitrosamines (TSNA), that are substrates of metabolizing enzymes generating reactive metabolites that can bind to DNA. Variation in the activity of these enzymes may modify the extent to which these metabolites can interact with DNA. We compared the levels of bulky DNA adducts in blood leukocytes from 93 volunteers living in Mexico City with the presence of 13 single nucleotide polymorphisms (SNPs) in genes related to PAH and TSNA metabolism (AhR rs2044853, CYP1A1 rs1048943, CYP1A1 rs1048943, CYP1A1 rs1799814, EPHX1 rs1051740, EPHX1 rs2234922, GSTM1 null, GSTT1 null and GSTP1 rs947894), DNA repair (XRCC1 rs25487, ERCC2 rs13181 and MGMT rs12917) and cell cycle (TP53 rs1042522). 32P-postlabeling analysis was used to quantify bulky DNA adduct formation. Genotyping was performed using PCR-RFLP. The mean levels of bulky DNA adducts were 8.51 ± 3.66 adducts/108 nucleotides (nt) in smokers and 8.38 ± 3.59 adducts/108 nt in non-smokers, being the difference not statistically significant. Without taking into account the smoking status, GSTM1null individuals had a marginally significant lower adduct levels compared with GSTM1 volunteers (p = 0.0433) and individuals heterozygous for MGMT Leu/Phe had a higher level of bulky adducts than those who were homozygous wild type (p = 0.0170). A multiple regression analysis model showed a significant association between the GSTM1 (deletion) and MGMT rs12917 (Phe/Phe) haplotype and the formation of DNA adducts in smokers (R2 = 0.2401, p = 0.0215). The presence of these variants conferred a greater risk for higher adduct levels in this Mexican population." @default.
- W2082003682 created "2016-06-24" @default.
- W2082003682 creator A5017202352 @default.
- W2082003682 creator A5018320285 @default.
- W2082003682 creator A5021392701 @default.
- W2082003682 creator A5034188143 @default.
- W2082003682 creator A5034816567 @default.
- W2082003682 creator A5042751476 @default.
- W2082003682 creator A5044059593 @default.
- W2082003682 creator A5087622113 @default.
- W2082003682 date "2013-12-01" @default.
- W2082003682 modified "2023-10-03" @default.
- W2082003682 title "The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes" @default.
- W2082003682 cites W1501286679 @default.
- W2082003682 cites W1596796792 @default.
- W2082003682 cites W1966066863 @default.
- W2082003682 cites W1970502777 @default.
- W2082003682 cites W1971344938 @default.
- W2082003682 cites W1977439202 @default.
- W2082003682 cites W1978146094 @default.
- W2082003682 cites W1983585455 @default.
- W2082003682 cites W1987152771 @default.
- W2082003682 cites W1988151751 @default.
- W2082003682 cites W1992051080 @default.
- W2082003682 cites W1994700344 @default.
- W2082003682 cites W2008586121 @default.
- W2082003682 cites W2009928548 @default.
- W2082003682 cites W2014455203 @default.
- W2082003682 cites W2019788334 @default.
- W2082003682 cites W2024160652 @default.
- W2082003682 cites W2025515800 @default.
- W2082003682 cites W2027548206 @default.
- W2082003682 cites W2030005694 @default.
- W2082003682 cites W2030132169 @default.
- W2082003682 cites W2033893102 @default.
- W2082003682 cites W2042195030 @default.
- W2082003682 cites W2045928184 @default.
- W2082003682 cites W2049091164 @default.
- W2082003682 cites W2049270112 @default.
- W2082003682 cites W2053434314 @default.
- W2082003682 cites W2053567500 @default.
- W2082003682 cites W2055315999 @default.
- W2082003682 cites W2059874056 @default.
- W2082003682 cites W2061952276 @default.
- W2082003682 cites W2063222926 @default.
- W2082003682 cites W2070611230 @default.
- W2082003682 cites W2075287906 @default.
- W2082003682 cites W2097111597 @default.
- W2082003682 cites W2103324761 @default.
- W2082003682 cites W2103416708 @default.
- W2082003682 cites W2105673666 @default.
- W2082003682 cites W2107287791 @default.
- W2082003682 cites W2112472493 @default.
- W2082003682 cites W2112710602 @default.
- W2082003682 cites W2123070547 @default.
- W2082003682 cites W2125807609 @default.
- W2082003682 cites W2131602976 @default.
- W2082003682 cites W2141502720 @default.
- W2082003682 cites W2142004135 @default.
- W2082003682 cites W2142427369 @default.
- W2082003682 cites W2151164163 @default.
- W2082003682 cites W2159611805 @default.
- W2082003682 cites W2162805437 @default.
- W2082003682 cites W2163930572 @default.
- W2082003682 cites W2166246430 @default.
- W2082003682 cites W4242981318 @default.
- W2082003682 cites W4246230065 @default.
- W2082003682 doi "https://doi.org/10.1016/j.mrgentox.2013.09.007" @default.
- W2082003682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24084248" @default.
- W2082003682 hasPublicationYear "2013" @default.
- W2082003682 type Work @default.
- W2082003682 sameAs 2082003682 @default.
- W2082003682 citedByCount "16" @default.
- W2082003682 countsByYear W20820036822015 @default.
- W2082003682 countsByYear W20820036822016 @default.
- W2082003682 countsByYear W20820036822017 @default.
- W2082003682 countsByYear W20820036822018 @default.
- W2082003682 countsByYear W20820036822019 @default.
- W2082003682 countsByYear W20820036822021 @default.
- W2082003682 countsByYear W20820036822022 @default.
- W2082003682 crossrefType "journal-article" @default.
- W2082003682 hasAuthorship W2082003682A5017202352 @default.
- W2082003682 hasAuthorship W2082003682A5018320285 @default.
- W2082003682 hasAuthorship W2082003682A5021392701 @default.
- W2082003682 hasAuthorship W2082003682A5034188143 @default.
- W2082003682 hasAuthorship W2082003682A5034816567 @default.
- W2082003682 hasAuthorship W2082003682A5042751476 @default.
- W2082003682 hasAuthorship W2082003682A5044059593 @default.
- W2082003682 hasAuthorship W2082003682A5087622113 @default.
- W2082003682 hasBestOaLocation W20820036822 @default.
- W2082003682 hasConcept C104317684 @default.
- W2082003682 hasConcept C108204754 @default.
- W2082003682 hasConcept C114246631 @default.
- W2082003682 hasConcept C134935766 @default.
- W2082003682 hasConcept C135763542 @default.
- W2082003682 hasConcept C143425029 @default.
- W2082003682 hasConcept C153209595 @default.
- W2082003682 hasConcept C153911025 @default.