FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082019631> ?p ?o ?g. }

• W2082019631 endingPage "4112" @default.
• W2082019631 startingPage "4100" @default.
• W2082019631 abstract "ABSTRACT Data from the RV144 HIV vaccine trial indicated that gp120 V2 antibodies were associated with a lower risk of infection; thus, the mapping of V2 epitopes can contribute to the design of an effective HIV vaccine. We solved the crystal structure of human monoclonal antibody (MAb) 2158, which targets a conformational V2 epitope overlapping the α4β7 integrin binding site, and constructed a full-length model of V1V2. Comparison of computational energy stability to experimental enzyme-linked immunosorbent assay (ELISA) results identified a hydrophobic core that stabilizes the V2 region for optimal 2158 binding, as well as residues that directly mediate side chain interactions with MAb 2158. These data define the binding surface recognized by MAb 2158 and offer a structural explanation for why a mismatched mutation at position 181 (I181X) in the V2 loop was associated with a higher vaccine efficiency in the RV144 clinical vaccine trial. IMPORTANCE Correlate analysis of the RV144 HIV-1 vaccine trial suggested that the presence of antibodies to the second variable region (V2) of HIV-1 gp120 was responsible for the modest protection observed in the trial. V2 is a highly variable and immunogenic region, and structural information on its antigenic landscape will be important for rational design of an effective HIV-1 vaccine. Using X-ray crystallography, computational design tools, and mutagenesis assays, we carried out a detailed and systematic investigation of the epitope recognition of human V2 MAb 2158 and demonstrated that its epitope region overlaps the integrin binding site within V2. In addition, we propose a structure-based mechanism for mismatching of the isoleucine at position 181 and the increased vaccine efficacy seen in the RV144 vaccine trial." @default.
• W2082019631 created "2016-06-24" @default.
• W2082019631 creator A5014692577 @default.
• W2082019631 creator A5024873083 @default.
• W2082019631 creator A5027075998 @default.
• W2082019631 creator A5041332295 @default.
• W2082019631 creator A5067196402 @default.
• W2082019631 date "2014-04-15" @default.
• W2082019631 modified "2023-10-15" @default.
• W2082019631 title "Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV" @default.
• W2082019631 cites W1966607693 @default.
• W2082019631 cites W1970326640 @default.
• W2082019631 cites W1985145726 @default.
• W2082019631 cites W1995466180 @default.
• W2082019631 cites W1999483871 @default.
• W2082019631 cites W2000443388 @default.
• W2082019631 cites W2000885937 @default.
• W2082019631 cites W2008679330 @default.
• W2082019631 cites W2010996470 @default.
• W2082019631 cites W2012816187 @default.
• W2082019631 cites W2016180326 @default.
• W2082019631 cites W2020231665 @default.
• W2082019631 cites W2023604714 @default.
• W2082019631 cites W2035864527 @default.
• W2082019631 cites W2043409853 @default.
• W2082019631 cites W2052745304 @default.
• W2082019631 cites W2053197719 @default.
• W2082019631 cites W2055043387 @default.
• W2082019631 cites W2062204035 @default.
• W2082019631 cites W2064508445 @default.
• W2082019631 cites W2065353103 @default.
• W2082019631 cites W2066143642 @default.
• W2082019631 cites W2072075694 @default.
• W2082019631 cites W2072675037 @default.
• W2082019631 cites W2076188553 @default.
• W2082019631 cites W2077247092 @default.
• W2082019631 cites W2083726777 @default.
• W2082019631 cites W2086382571 @default.
• W2082019631 cites W2094750078 @default.
• W2082019631 cites W2099576234 @default.
• W2082019631 cites W2106372377 @default.
• W2082019631 cites W2108959691 @default.
• W2082019631 cites W2109184569 @default.
• W2082019631 cites W2109683366 @default.
• W2082019631 cites W2113190656 @default.
• W2082019631 cites W2117020466 @default.
• W2082019631 cites W2117450920 @default.
• W2082019631 cites W2122617162 @default.
• W2082019631 cites W2131039822 @default.
• W2082019631 cites W2131896393 @default.
• W2082019631 cites W2133956851 @default.
• W2082019631 cites W2143421242 @default.
• W2082019631 cites W2144081223 @default.
• W2082019631 cites W2147949826 @default.
• W2082019631 cites W2152048324 @default.
• W2082019631 cites W2153457180 @default.
• W2082019631 cites W2157820405 @default.
• W2082019631 cites W2159593123 @default.
• W2082019631 cites W2159795515 @default.
• W2082019631 cites W2159814435 @default.
• W2082019631 cites W2163341755 @default.
• W2082019631 cites W2167477934 @default.
• W2082019631 doi "https://doi.org/10.1128/jvi.03153-13" @default.
• W2082019631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3993739" @default.
• W2082019631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24478429" @default.
• W2082019631 hasPublicationYear "2014" @default.
• W2082019631 type Work @default.
• W2082019631 sameAs 2082019631 @default.
• W2082019631 citedByCount "38" @default.
• W2082019631 countsByYear W20820196312014 @default.
• W2082019631 countsByYear W20820196312015 @default.
• W2082019631 countsByYear W20820196312016 @default.
• W2082019631 countsByYear W20820196312017 @default.
• W2082019631 countsByYear W20820196312018 @default.
• W2082019631 countsByYear W20820196312019 @default.
• W2082019631 countsByYear W20820196312020 @default.
• W2082019631 countsByYear W20820196312021 @default.
• W2082019631 countsByYear W20820196312022 @default.
• W2082019631 crossrefType "journal-article" @default.
• W2082019631 hasAuthorship W2082019631A5014692577 @default.
• W2082019631 hasAuthorship W2082019631A5024873083 @default.
• W2082019631 hasAuthorship W2082019631A5027075998 @default.
• W2082019631 hasAuthorship W2082019631A5041332295 @default.
• W2082019631 hasAuthorship W2082019631A5067196402 @default.
• W2082019631 hasBestOaLocation W20820196311 @default.
• W2082019631 hasConcept C159047783 @default.
• W2082019631 hasConcept C159654299 @default.
• W2082019631 hasConcept C195616568 @default.
• W2082019631 hasConcept C22070199 @default.
• W2082019631 hasConcept C2778190748 @default.
• W2082019631 hasConcept C2780195530 @default.
• W2082019631 hasConcept C2780441014 @default.
• W2082019631 hasConcept C2781241564 @default.
• W2082019631 hasConcept C3013748606 @default.
• W2082019631 hasConcept C542903549 @default.
• W2082019631 hasConcept C54355233 @default.
• W2082019631 hasConcept C70721500 @default.
• W2082019631 hasConcept C86803240 @default.

• next