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- W2082020318 abstract "To evaluate the efficacy and safety of aripiprazole and perospirone in Japanese patients with schizophrenia. In this 12-week, randomized, flexible-dose, open-label study, patients diagnosed with schizophrenia were randomized to receive aripiprazole (3–30 mg/day, n = 49) or perospirone (8–48 mg/day, n = 51). Efficacy and safety were evaluated using the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression-Severity Scale (CGI-S), the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) and the Barnes Akathisia Rating Scale (BAS) before treatment and every 4 weeks after the initiation of treatment. Fifty-eight patients completed this study (aripiprazole, n = 31; perospirone, n = 27). No significant differences in gender, episode, age, schizophrenia type, weight, previous treatment and PANSS score were observed between the two groups at baseline. Both groups showed significant improvements during the study, with reductions in the total PANSS scores (Repeated measure analysis of variance, both p < 0.0001). There were no significant differences in the PANSS change scores, CGI-S change scores, DIEPSS total score, BAS total score or over time between groups. The most common adverse event was insomnia in both groups. In Japanese schizophrenia patients, aripiprazole and perospirone showed equal efficacy, tolerability and patient compliance. Both drugs showed good efficacy for treating schizophrenia. This paper is the first randomized study to evaluate the comparative efficacy and safety of aripiprazole and perospirone in the treatment of patients with schizophrenia." @default.
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- W2082020318 date "2013-01-01" @default.
- W2082020318 modified "2023-09-30" @default.
- W2082020318 title "A 12-week randomized, open-label study of perospirone versus aripiprazole in the treatment of Japanese schizophrenia patients" @default.
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- W2082020318 doi "https://doi.org/10.1016/j.pnpbp.2012.09.010" @default.
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