Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082022170> ?p ?o ?g. }
- W2082022170 endingPage "119" @default.
- W2082022170 startingPage "109" @default.
- W2082022170 abstract "Previously tumorigenic P815 tumor cells are rejected by histocompatible mice after transfection with a mutated retroviral gene, and the host is made resistant to subsequent challenge with tumorigenic (control) cells transfected with the nonmutated sequence. To functionally characterize the class I-restricted response to the tumor cell vaccine, we have assessed thein vitro(by CD8+cells) andin vivoproduction of type 1 or type 2 cytokines in mice injected with either type of transfected P815 derivative. IL-12 and IL-10 were selectively or preferentially expressed by the regressor mice, and this correlated with the detection of functional type 1 reactivityin vivo(i.e., delayed-type hypersensitivity). Other cytokines were produced by the regressor mice onlyin vitro(IFN-γ) or were not detected at all with either type of tumor recipient (IL-4). By means of monoclonal antibody-mediated neutralization or enhancement of endogenous cytokine levels, IL-10 was found to serve an important role in the growth and rejection patterns of the transfected P815 derivatives. In addition to previous evidence for an IL-12 requirement in promoting anti-P815 reactivity, these data establish IL-10 as an important cytokine in permitting optimal expression of this reactivity, which apparently develops in the absence of a strong bias toward a type 1 or type 2 cytokine response." @default.
- W2082022170 created "2016-06-24" @default.
- W2082022170 creator A5003492189 @default.
- W2082022170 creator A5011703773 @default.
- W2082022170 creator A5019976224 @default.
- W2082022170 creator A5021481850 @default.
- W2082022170 creator A5045015927 @default.
- W2082022170 creator A5047813375 @default.
- W2082022170 creator A5079557352 @default.
- W2082022170 date "1997-11-01" @default.
- W2082022170 modified "2023-10-05" @default.
- W2082022170 title "Circulating Levels of IL-10 Are Critically Related to Growth and Rejection Patterns of Murine Mastocytoma Cells" @default.
- W2082022170 cites W1495915055 @default.
- W2082022170 cites W1501613786 @default.
- W2082022170 cites W1502749381 @default.
- W2082022170 cites W1517849046 @default.
- W2082022170 cites W1543625048 @default.
- W2082022170 cites W1591161561 @default.
- W2082022170 cites W1650597323 @default.
- W2082022170 cites W1654658858 @default.
- W2082022170 cites W1671840178 @default.
- W2082022170 cites W1773775383 @default.
- W2082022170 cites W1891447727 @default.
- W2082022170 cites W1941619275 @default.
- W2082022170 cites W1942668068 @default.
- W2082022170 cites W1947284792 @default.
- W2082022170 cites W1972922050 @default.
- W2082022170 cites W1979514172 @default.
- W2082022170 cites W1981787863 @default.
- W2082022170 cites W1991858842 @default.
- W2082022170 cites W1991934910 @default.
- W2082022170 cites W1996671893 @default.
- W2082022170 cites W2015419033 @default.
- W2082022170 cites W2018084769 @default.
- W2082022170 cites W2019424369 @default.
- W2082022170 cites W2022022413 @default.
- W2082022170 cites W2028548278 @default.
- W2082022170 cites W2030261077 @default.
- W2082022170 cites W2034124899 @default.
- W2082022170 cites W2061454348 @default.
- W2082022170 cites W2074969851 @default.
- W2082022170 cites W2076803670 @default.
- W2082022170 cites W2092629366 @default.
- W2082022170 cites W2100427081 @default.
- W2082022170 cites W2102808804 @default.
- W2082022170 cites W2105100673 @default.
- W2082022170 cites W2115954882 @default.
- W2082022170 cites W2126648878 @default.
- W2082022170 cites W2126751198 @default.
- W2082022170 cites W2170889183 @default.
- W2082022170 cites W2172009488 @default.
- W2082022170 cites W2175077154 @default.
- W2082022170 cites W2183790775 @default.
- W2082022170 cites W3021254998 @default.
- W2082022170 cites W4249464132 @default.
- W2082022170 doi "https://doi.org/10.1006/cimm.1997.1190" @default.
- W2082022170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9398398" @default.
- W2082022170 hasPublicationYear "1997" @default.
- W2082022170 type Work @default.
- W2082022170 sameAs 2082022170 @default.
- W2082022170 citedByCount "5" @default.
- W2082022170 crossrefType "journal-article" @default.
- W2082022170 hasAuthorship W2082022170A5003492189 @default.
- W2082022170 hasAuthorship W2082022170A5011703773 @default.
- W2082022170 hasAuthorship W2082022170A5019976224 @default.
- W2082022170 hasAuthorship W2082022170A5021481850 @default.
- W2082022170 hasAuthorship W2082022170A5045015927 @default.
- W2082022170 hasAuthorship W2082022170A5047813375 @default.
- W2082022170 hasAuthorship W2082022170A5079557352 @default.
- W2082022170 hasConcept C134018914 @default.
- W2082022170 hasConcept C153911025 @default.
- W2082022170 hasConcept C159654299 @default.
- W2082022170 hasConcept C16613235 @default.
- W2082022170 hasConcept C167672396 @default.
- W2082022170 hasConcept C191732599 @default.
- W2082022170 hasConcept C202751555 @default.
- W2082022170 hasConcept C203014093 @default.
- W2082022170 hasConcept C207001950 @default.
- W2082022170 hasConcept C2778690821 @default.
- W2082022170 hasConcept C2778930412 @default.
- W2082022170 hasConcept C54009773 @default.
- W2082022170 hasConcept C542903549 @default.
- W2082022170 hasConcept C54355233 @default.
- W2082022170 hasConcept C81885089 @default.
- W2082022170 hasConcept C86803240 @default.
- W2082022170 hasConcept C8891405 @default.
- W2082022170 hasConceptScore W2082022170C134018914 @default.
- W2082022170 hasConceptScore W2082022170C153911025 @default.
- W2082022170 hasConceptScore W2082022170C159654299 @default.
- W2082022170 hasConceptScore W2082022170C16613235 @default.
- W2082022170 hasConceptScore W2082022170C167672396 @default.
- W2082022170 hasConceptScore W2082022170C191732599 @default.
- W2082022170 hasConceptScore W2082022170C202751555 @default.
- W2082022170 hasConceptScore W2082022170C203014093 @default.
- W2082022170 hasConceptScore W2082022170C207001950 @default.
- W2082022170 hasConceptScore W2082022170C2778690821 @default.
- W2082022170 hasConceptScore W2082022170C2778930412 @default.
- W2082022170 hasConceptScore W2082022170C54009773 @default.