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- W2082022809 abstract "The seemingly long half-life of antibody-producing plasma cells demonstrated by antigen-binding (ELISA type of) assays as compared with the short-livedness of neutralizing and protective antibody-producing plasma cells is explained here by the heterogeneity and multiple crossreactive antibodies detected by ELISA-type assays. While DNP-specific B cell frequencies are about 10(-2) that of virus, serotype-specific B cell frequencies are about 10(-5)-10(-6). Therefore, the seemingly long-lived multiple low-affinity crossreactive antibody-producing plasma cells represent a collective of little if any biological or evolutionary relevance. The plasma cells producing high-affinity protective, neutralizing antibodies (>10(9) M(-1)) in mice are short-lived and therefore continued antibody production is dependent on antigen exposure from within (immune complexes and persistence of infections) or from without by epidemiologically circulating infectious agents, or by revaccinations." @default.
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- W2082022809 date "2014-06-07" @default.
- W2082022809 modified "2023-10-16" @default.
- W2082022809 title "On plasma cell longevity or brevity" @default.
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- W2082022809 doi "https://doi.org/10.1586/14760584.2014.924402" @default.
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