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• W2082024360 startingPage "10338" @default.
• W2082024360 abstract "Cytotoxic T cells recognize mosaic structures consisting of target peptides embedded within self-major histocompatibility complex (MHC) class I molecules. This structure has been described in great detail for several peptide-MHC complexes. In contrast, how T-cell receptors recognize peptide-MHC complexes have been less well characterized. We have used a complete set of singly substituted analogs of a mouse MHC class I, Kk-restricted peptide, influenza hemagglutinin (Ha)255-262, to address the binding specificity of this MHC molecule. Using the same peptide-MHC complexes we determined the fine specificity of two Ha255-262-specific, Kk-restricted T cells, and of a unique antibody, pSAN, specific for the same peptide-MHC complex. Independently, a model of the Ha255-262-Kk complex was generated through homology modeling and molecular mechanics refinement. The functional data and the model corroborated each other showing that peptide residues 1, 3, 4, 6, and 7 were exposed on the MHC surface and recognized by the T cells. Thus, the majority, and perhaps all, of the side chains of the non-primary anchor residues may be available for T-cell recognition, and contribute to the stringent specificity of T cells. A striking similarity between the specificity of the T cells and that of the pSAN antibody was found and most of the peptide residues, which could be recognized by the T cells, could also be recognized by the antibody." @default.
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• W2082024360 date "1996-09-17" @default.
• W2082024360 modified "2023-09-23" @default.
• W2082024360 title "Shared fine specificity between T-cell receptors and an antibody recognizing a peptide/major histocompatibility class I complex." @default.
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• W2082024360 doi "https://doi.org/10.1073/pnas.93.19.10338" @default.
• W2082024360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38385" @default.
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