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• W2082032461 abstract "Although neutralizing antigenic sites of foot-and-mouth disease virus (FMDV) can be defined by selection of monoclonal antibody (MAb) escape mutants, no conformational neutralizing epitope on the major antigenic site located on the G-H loop of type Asia1 FMDV has been precisely mapped. In this study, we generated a potent neutralizing MAb 3E11, which recognized a conformation-dependent epitope and neutralized FMDV Asia1/YS/CHA/05 in vitro. Importantly, a dose of 5.5 NT(50) of the MAb 3E11 completely protected suckling mice from a dose of 10 LD(50) of homologous virus challenge in vivo. Through a 12-mer random peptide phage display, synthetic peptide analysis and constructing a series of FMDV Asia1/YS/CHA/05 mutants using reverse genetic system, we finely mapped the neutralizing epitope as the 12-amino acid peptide (141)SXRGXLXXLXRR(152). These results provide additional insights into the virus-MAb interaction at the amino acid level and may help in the development of an epitope-based Asia1 FMDV vaccine." @default.
• W2082032461 created "2016-06-24" @default.
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• W2082032461 date "2011-03-24" @default.
• W2082032461 modified "2023-10-16" @default.
• W2082032461 title "Identification of a conformational epitope on the VP1 G-H Loop of type Asia1 foot-and-mouth disease virus defined by a protective monoclonal antibody" @default.
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• W2082032461 doi "https://doi.org/10.1016/j.vetmic.2010.09.013" @default.
• W2082032461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20961714" @default.
• W2082032461 hasPublicationYear "2011" @default.
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