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• W2082037386 abstract "On its upstream side, the human interferon-beta gene is flanked by a 7-kb SAR (scaffold-attached region) DNA element. The core of this element is determined and subjected to in vitro reassociations with isolated scaffolds. Binding properties of SAR fragments with decreasing length are quantified and related to consensus sequences like the topoisomerase II box and an ATATTT motif. Characteristics as the stoichiometry, affinity, and cooperativity of the binding process are shown to depend on the length of SAR DNA and suggest a model involving a multiple-site attachment to protein scaffolds. We propose a rational approach for predicting the SAR mediated transcriptional enhancements in vivo from their binding properties in a standardized in vitro assay. The efficiency of this approach is demonstrated for a marker (huIFN-beta) and a selector gene (neor)." @default.
• W2082037386 created "2016-06-24" @default.
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• W2082037386 date "1990-08-14" @default.
• W2082037386 modified "2023-09-27" @default.
• W2082037386 title "Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo" @default.
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• W2082037386 doi "https://doi.org/10.1021/bi00484a017" @default.
• W2082037386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2223779" @default.
• W2082037386 hasPublicationYear "1990" @default.
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