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- W2082056288 abstract "A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to understand the underlying mechanisms that contribute to the purported benefits of OL-HDF, we examined the potential role and impact of OL-HDF on key stages of anemia and its correction: erythropoiesis of bone marrow, circulating erythrocytes and on anemia therapy. We review evidence that indicates OL-HDF may modulate key processes of anemia and its therapy, including underlying conditions and responses of uremic toxicity and inflammation that aggravate anemia. Our assessment indicates that OL-HDF favorably impacts anemia by not only eliminating putative uremic inhibitors that suppress erythropoiesis, reducing red cell destruction and increasing iron availability, but also by mechanisms restricting underlying inflammation and endothelial dysfunction that are crucial to both CKD and anemia." @default.
- W2082056288 created "2016-06-24" @default.
- W2082056288 creator A5011330507 @default.
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- W2082056288 date "2011-01-01" @default.
- W2082056288 modified "2023-10-14" @default.
- W2082056288 title "Impact of Hemodialysis Therapy on Anemia of Chronic Kidney Disease: The Potential Mechanisms" @default.
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- W2082056288 doi "https://doi.org/10.1159/000329573" @default.
- W2082056288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21811070" @default.
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