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- W2082056539 abstract "The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeostasis, protecting underlying cells against pathogens, dehydration, and damage. Assembly of the tight junction barrier is dependent upon neighboring epithelial cells binding to one another and forming adherens junctions, but the mechanism for how these processes are linked is poorly understood. Using a knockdown/substitution system, we studied if ZO-1 binding to α-catenin is required for coupling tight junction assembly to adherens junctions. We generated an α-catenin point mutant that does not bind ZO-1. We found that preventing ZO-1 binding to α-catenin severely disrupted the assembly and maintenance of an epithelial barrier by altering the mobility of ZO-1 and organization of the actin cytoskeleton. Under these conditions, the adherens junctions did not appear to be disrupted. Thus, our study identifies α-catenin binding to ZO-1 as a novel mechanism for coupling the tight junction barrier machinery to adherens junction adhesion complex." @default.
- W2082056539 created "2016-06-24" @default.
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- W2082056539 date "2013-01-01" @default.
- W2082056539 modified "2023-10-14" @default.
- W2082056539 title "ZO-1 recruitment to α-catenin: a novel mechanism for coupling the assembly of tight junctions to adherens junctions" @default.
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- W2082056539 doi "https://doi.org/10.1242/jcs.126565" @default.
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