FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082057885> ?p ?o ?g. }

• W2082057885 endingPage "1379" @default.
• W2082057885 startingPage "1379" @default.
• W2082057885 abstract "PURPOSE. Antimicrobial peptides are the eukaryotic analogues of antibiotics. In addition to their antimicrobial activity, these peptides can signal to host cells and are therefore intermediaries between the innate and adaptive immune systems. Results in a prior study showed that -defensins-1 and -2 are made by ocular surface epithelial cells. In the present study, a survey was made of antimicrobial peptide expression, including 17 previously described members of the -defensin family, at the surface of the human eye. METHODS. Total RNA was obtained from 43 fresh and cultured corneal and conjunctival samples, including 9 samples from patients with clinical infections. The expression of 21 antimicrobial peptides was determined using reverse transcriptionPCR. Where detected, relative expression was quantitated using real-time PCR. RESULTS. Expression of 7 of the 21 antimicrobial peptides investigated, -defensin-1 to -4, liver expressed antimicrobial peptide (LEAP)-1 and -2, and LL37/cathelicidin, were detected frequently in samples of ocular surface epithelia. Distinct but overlapping profiles of expression were detected in cornea and conjunctiva, with expression of -defensin-3 and -4 and LEAP1 and -2 most common in cultured corneal epithelia. Expression of -defensin-3 was detected in a greater percentage of corneal and conjunctival samples with infection. CONCLUSIONS. Together with known lacrimal antimicrobial activities, these results extend the knowledge of antimicrobial activity at an important mucosal site, the ocular surface, allowing synergistic interactions to be investigated. The findings has significant implications both for the understanding of the normal homeostasis of mucosal surfaces and for antimicrobial and anti-inflammatory therapies. (Invest Ophthalmol Vis Sci. 2005; 46:1379‐1385) DOI:10.1167/iovs.04-0607" @default.
• W2082057885 created "2016-06-24" @default.
• W2082057885 creator A5019498420 @default.
• W2082057885 creator A5026664368 @default.
• W2082057885 creator A5029449398 @default.
• W2082057885 creator A5038747956 @default.
• W2082057885 creator A5038831216 @default.
• W2082057885 creator A5069155228 @default.
• W2082057885 creator A5078138642 @default.
• W2082057885 creator A5085726720 @default.
• W2082057885 date "2005-04-01" @default.
• W2082057885 modified "2023-09-27" @default.
• W2082057885 title "The Spectrum of Antimicrobial Peptide Expression at the Ocular Surface" @default.
• W2082057885 cites W1511739548 @default.
• W2082057885 cites W1761222131 @default.
• W2082057885 cites W1875764348 @default.
• W2082057885 cites W1968931227 @default.
• W2082057885 cites W19739015 @default.
• W2082057885 cites W1985211498 @default.
• W2082057885 cites W1988228153 @default.
• W2082057885 cites W1989010036 @default.
• W2082057885 cites W1995053645 @default.
• W2082057885 cites W1995519698 @default.
• W2082057885 cites W2001526641 @default.
• W2082057885 cites W2003738186 @default.
• W2082057885 cites W2013675806 @default.
• W2082057885 cites W2014850470 @default.
• W2082057885 cites W2014941940 @default.
• W2082057885 cites W2023606718 @default.
• W2082057885 cites W2025206710 @default.
• W2082057885 cites W2028105938 @default.
• W2082057885 cites W2028501275 @default.
• W2082057885 cites W2030642888 @default.
• W2082057885 cites W2051142131 @default.
• W2082057885 cites W2054602599 @default.
• W2082057885 cites W2056222003 @default.
• W2082057885 cites W2058223359 @default.
• W2082057885 cites W2063219607 @default.
• W2082057885 cites W2066456239 @default.
• W2082057885 cites W2069609837 @default.
• W2082057885 cites W2073865475 @default.
• W2082057885 cites W2084954530 @default.
• W2082057885 cites W2104159258 @default.
• W2082057885 cites W2124508823 @default.
• W2082057885 cites W2125935614 @default.
• W2082057885 cites W2136538608 @default.
• W2082057885 cites W2138207315 @default.
• W2082057885 cites W2140015861 @default.
• W2082057885 cites W2141632987 @default.
• W2082057885 cites W2143635657 @default.
• W2082057885 cites W2144634347 @default.
• W2082057885 cites W2148381319 @default.
• W2082057885 cites W2148726348 @default.
• W2082057885 cites W2149548143 @default.
• W2082057885 cites W2150705960 @default.
• W2082057885 cites W2160780417 @default.
• W2082057885 cites W2162819583 @default.
• W2082057885 cites W2163389027 @default.
• W2082057885 cites W2165768410 @default.
• W2082057885 cites W2785991938 @default.
• W2082057885 cites W47011055 @default.
• W2082057885 cites W85985731 @default.
• W2082057885 doi "https://doi.org/10.1167/iovs.04-0607" @default.
• W2082057885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15790905" @default.
• W2082057885 hasPublicationYear "2005" @default.
• W2082057885 type Work @default.
• W2082057885 sameAs 2082057885 @default.
• W2082057885 citedByCount "67" @default.
• W2082057885 countsByYear W20820578852012 @default.
• W2082057885 countsByYear W20820578852013 @default.
• W2082057885 countsByYear W20820578852014 @default.
• W2082057885 countsByYear W20820578852016 @default.
• W2082057885 countsByYear W20820578852017 @default.
• W2082057885 countsByYear W20820578852018 @default.
• W2082057885 countsByYear W20820578852019 @default.
• W2082057885 countsByYear W20820578852020 @default.
• W2082057885 countsByYear W20820578852021 @default.
• W2082057885 countsByYear W20820578852022 @default.
• W2082057885 crossrefType "journal-article" @default.
• W2082057885 hasAuthorship W2082057885A5019498420 @default.
• W2082057885 hasAuthorship W2082057885A5026664368 @default.
• W2082057885 hasAuthorship W2082057885A5029449398 @default.
• W2082057885 hasAuthorship W2082057885A5038747956 @default.
• W2082057885 hasAuthorship W2082057885A5038831216 @default.
• W2082057885 hasAuthorship W2082057885A5069155228 @default.
• W2082057885 hasAuthorship W2082057885A5078138642 @default.
• W2082057885 hasAuthorship W2082057885A5085726720 @default.
• W2082057885 hasBestOaLocation W20820578851 @default.
• W2082057885 hasConcept C118487528 @default.
• W2082057885 hasConcept C185592680 @default.
• W2082057885 hasConcept C199360897 @default.
• W2082057885 hasConcept C2779281246 @default.
• W2082057885 hasConcept C41008148 @default.
• W2082057885 hasConcept C4937899 @default.
• W2082057885 hasConcept C540938839 @default.
• W2082057885 hasConcept C55493867 @default.
• W2082057885 hasConcept C71924100 @default.
• W2082057885 hasConcept C86803240 @default.

• next