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• W2082073676 abstract "Mineralized bone formation in vitro can be induced by the alkaline phosphatase substrate β-glycerophosphate (GP). GP may not only be essential for mineralization in vitro, but could also modulate other metabolic activities of bone cells, particularly if GP is presented to these cells during different phases of development. To assess GP modulation of bone cell metabolism, biochemical and autoradiographic analyses of chick periosteal cultures treated with GP were performed. About 50% less (p < 0.05) Type I collagen was produced in periosteal cultures treated with GP. If the fibrous portion of the periostem was microdissected from the osteogenic layer prior to culture, GP inhibition of Type I collagen synthesis was even more marked (60%: p < 0.05). To define organic phosphate-sensitive phases of osteogenesis, cultures were exposed to GP for various time periods. Mineralization occurred reproducibly when periosteal cultures were treated with GP from the outset of the incubation period (positive control). However, if GP was added after the third day of incubation, phosphate content was the same as in positive control cultures, whereas calcium content was significantly (20%: p < 0.05) lower. Moreover, if GP was added on day 6, there was virtually no calcium accumulation by day 12, while massive amounts of phosphate had accumulated. Taken together, these findings indicate that organic phosphates may modulate phenotypic expression of osteogenic cells, and that osteogenic cells traverse an organic phosphate-sensitive phase, after which they may be incapable of normal mineralization." @default.
• W2082073676 created "2016-06-24" @default.
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• W2082073676 date "1992-01-01" @default.
• W2082073676 modified "2023-10-16" @default.
• W2082073676 title "Osteogenic phase-specific co-regulation of collagen synthesis and mineralization by β-glycerophosphate in chick periosteal cultures" @default.
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• W2082073676 doi "https://doi.org/10.1016/8756-3282(92)90002-e" @default.
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