FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082074091> ?p ?o ?g. }

• W2082074091 endingPage "68" @default.
• W2082074091 startingPage "53" @default.
• W2082074091 abstract "Tumors of B lymphocyte origin have been used as models for normal B cells “frozen” at particular stages of their development. Surface properties, amount, and intracellular location of immunoglobulin and the synthesis of J chain have all been used as indicators of developmental stages. Each requires special techniques or yields data that are difficult to compare from one experiment to the next. For these reasons, we have developed a metric for B cell development that is simple to perform and allows quick quantitative comparisons of cell lines. It has recently been established that the membrane (μm) and secreted (μs) forms of the IgM heavy chain differ at their extreme carboxy termini. The two proteins differ slightly in size and are easily distinguished when they are compared without their carbohydrate on sodium dodecyl sulfate (SDS) polyacrylamide gels. We have examined four mouse tumors derived from the B lymphocyte lineage whose phenotypes resemble late pre-B cells (internal μ only; uninduced 70Z/3), small B lymphocytes (high levels of surface IgM; LPS-induced 70Z/3, WEHI 231), lymphoblasts (both membrane and secreted IgM; WEHI 279.1), and plasma cells (copious IgM secretion; MOPC 104E). Despite the fact the 70Z/3 and WEHI 231 secrete no detectable IgM, all of the tumors synthesize at least intracellular forms of both μm and μs. The proportion of μm is stable and is characteristic of each tumor. The 70Z/3 cells and WEHI 231 cells synthesize about 75% of their total μ as μm; WEHI 279.1 cells synthesize about 30% and MOPC 104E cells about 5% of their total μ as μm. The population of LPS-stimulated B lymphocytes shows a similar progression during its differentiation. The proportion of μm correlates with other developmentally regulated parameters (Fc receptor, Ia and plasma cell antigen levels, and J chain) and can be used as a simple metric for comparison with developing B lymphocytes and determination of the developmental stage of a B cell tumor." @default.
• W2082074091 created "2016-06-24" @default.
• W2082074091 creator A5002903850 @default.
• W2082074091 creator A5051904927 @default.
• W2082074091 creator A5063736233 @default.
• W2082074091 date "1982-01-01" @default.
• W2082074091 modified "2023-10-16" @default.
• W2082074091 title "The intracellular ratio of the membrane to the secreted form of immunoglobulin M heavy chain is a measure of the developmental stage of B cell lymphomas" @default.
• W2082074091 cites W1476591324 @default.
• W2082074091 cites W1570776822 @default.
• W2082074091 cites W1582025453 @default.
• W2082074091 cites W1628932770 @default.
• W2082074091 cites W1638408639 @default.
• W2082074091 cites W1963704405 @default.
• W2082074091 cites W1971139386 @default.
• W2082074091 cites W1976054932 @default.
• W2082074091 cites W2001154029 @default.
• W2082074091 cites W2009580887 @default.
• W2082074091 cites W2023106932 @default.
• W2082074091 cites W2036744348 @default.
• W2082074091 cites W2038901856 @default.
• W2082074091 cites W2042708086 @default.
• W2082074091 cites W2043606640 @default.
• W2082074091 cites W2045116343 @default.
• W2082074091 cites W2046220244 @default.
• W2082074091 cites W2054120235 @default.
• W2082074091 cites W2060393008 @default.
• W2082074091 cites W2062581415 @default.
• W2082074091 cites W2070017545 @default.
• W2082074091 cites W2071270693 @default.
• W2082074091 cites W2072790506 @default.
• W2082074091 cites W2085062936 @default.
• W2082074091 cites W2086119957 @default.
• W2082074091 cites W2086252935 @default.
• W2082074091 cites W2100837269 @default.
• W2082074091 cites W2115713211 @default.
• W2082074091 cites W2133159445 @default.
• W2082074091 cites W2134192381 @default.
• W2082074091 cites W2137783265 @default.
• W2082074091 cites W2166780858 @default.
• W2082074091 cites W2168582694 @default.
• W2082074091 cites W2585157458 @default.
• W2082074091 cites W4249553124 @default.
• W2082074091 cites W4313313455 @default.
• W2082074091 cites W4313338579 @default.
• W2082074091 doi "https://doi.org/10.1002/dvg.1020030106" @default.
• W2082074091 hasPublicationYear "1982" @default.
• W2082074091 type Work @default.
• W2082074091 sameAs 2082074091 @default.
• W2082074091 citedByCount "5" @default.
• W2082074091 crossrefType "journal-article" @default.
• W2082074091 hasAuthorship W2082074091A5002903850 @default.
• W2082074091 hasAuthorship W2082074091A5051904927 @default.
• W2082074091 hasAuthorship W2082074091A5063736233 @default.
• W2082074091 hasConcept C113842279 @default.
• W2082074091 hasConcept C153911025 @default.
• W2082074091 hasConcept C159654299 @default.
• W2082074091 hasConcept C203014093 @default.
• W2082074091 hasConcept C2777761686 @default.
• W2082074091 hasConcept C2778453870 @default.
• W2082074091 hasConcept C2911212856 @default.
• W2082074091 hasConcept C36394416 @default.
• W2082074091 hasConcept C48010095 @default.
• W2082074091 hasConcept C49039625 @default.
• W2082074091 hasConcept C54355233 @default.
• W2082074091 hasConcept C55493867 @default.
• W2082074091 hasConcept C79879829 @default.
• W2082074091 hasConcept C81885089 @default.
• W2082074091 hasConcept C84613547 @default.
• W2082074091 hasConcept C86803240 @default.
• W2082074091 hasConcept C97615245 @default.
• W2082074091 hasConceptScore W2082074091C113842279 @default.
• W2082074091 hasConceptScore W2082074091C153911025 @default.
• W2082074091 hasConceptScore W2082074091C159654299 @default.
• W2082074091 hasConceptScore W2082074091C203014093 @default.
• W2082074091 hasConceptScore W2082074091C2777761686 @default.
• W2082074091 hasConceptScore W2082074091C2778453870 @default.
• W2082074091 hasConceptScore W2082074091C2911212856 @default.
• W2082074091 hasConceptScore W2082074091C36394416 @default.
• W2082074091 hasConceptScore W2082074091C48010095 @default.
• W2082074091 hasConceptScore W2082074091C49039625 @default.
• W2082074091 hasConceptScore W2082074091C54355233 @default.
• W2082074091 hasConceptScore W2082074091C55493867 @default.
• W2082074091 hasConceptScore W2082074091C79879829 @default.
• W2082074091 hasConceptScore W2082074091C81885089 @default.
• W2082074091 hasConceptScore W2082074091C84613547 @default.
• W2082074091 hasConceptScore W2082074091C86803240 @default.
• W2082074091 hasConceptScore W2082074091C97615245 @default.
• W2082074091 hasIssue "1" @default.
• W2082074091 hasLocation W20820740911 @default.
• W2082074091 hasOpenAccess W2082074091 @default.
• W2082074091 hasPrimaryLocation W20820740911 @default.
• W2082074091 hasRelatedWork W1521078807 @default.
• W2082074091 hasRelatedWork W1975242127 @default.
• W2082074091 hasRelatedWork W1995420106 @default.
• W2082074091 hasRelatedWork W1996856765 @default.
• W2082074091 hasRelatedWork W2051647313 @default.
• W2082074091 hasRelatedWork W2085369238 @default.

• next