FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082085050> ?p ?o ?g. }

• W2082085050 endingPage "2863" @default.
• W2082085050 startingPage "2853" @default.
• W2082085050 abstract "Precise control of the timing of translational activation of dormant mRNAs stored in oocytes is required for normal progression of oocyte maturation. We previously showed that Pumilio1 (Pum1) is specifically involved in the translational control of cyclin B1 mRNA during Xenopus oocyte maturation, in cooperation with cytoplasmic polyadenylation element-binding protein (CPEB). It was reported that another Pumilio, Pumilio2 (Pum2), exists in Xenopus oocytes and that this protein regulates the translation of RINGO mRNA, together with Deleted in Azoospermia-like protein (DAZL). In this study, we characterized Pum1 and Pum2 biochemically by using newly produced antibodies that discriminate between them. Pum1 and Pum2 are bound to several key proteins involved in translational control of dormant mRNAs, including CPEB and DAZL, in immature oocytes. However, Pum1 and Pum2 themselves have no physical interaction. Injection of anti-Pum1 or anti-Pum2 antibody accelerated CPEB phosphorylation, cyclin B1 translation, and oocyte maturation. Pum1 phosphorylation coincides with the dissociation of CPEB from Pum1 and the translational activation of cyclin B1 mRNA, a target of Pum1, whereas Pum2 phosphorylation occurred at timing earlier than that for Pum1. Some, but not all, of cyclin B1 mRNAs release the deadenylase PARN during oocyte maturation, whereas Pum1 remains associated with the mRNA. On the basis of these findings, we discuss the functions of Pum1 and Pum2 in translational control of mRNAs during oocyte maturation." @default.
• W2082085050 created "2016-06-24" @default.
• W2082085050 creator A5061728715 @default.
• W2082085050 creator A5076361927 @default.
• W2082085050 creator A5080910218 @default.
• W2082085050 date "2011-01-01" @default.
• W2082085050 modified "2023-09-30" @default.
• W2082085050 title "Biochemical Characterization of Pumilio1 and Pumilio2 in Xenopus Oocytes" @default.
• W2082085050 cites W1567310074 @default.
• W2082085050 cites W1595865541 @default.
• W2082085050 cites W1680105951 @default.
• W2082085050 cites W1965036967 @default.
• W2082085050 cites W1968283108 @default.
• W2082085050 cites W1969635818 @default.
• W2082085050 cites W1973050238 @default.
• W2082085050 cites W1973191446 @default.
• W2082085050 cites W1973814530 @default.
• W2082085050 cites W1975350101 @default.
• W2082085050 cites W1976515716 @default.
• W2082085050 cites W1980084095 @default.
• W2082085050 cites W1982752345 @default.
• W2082085050 cites W1987777270 @default.
• W2082085050 cites W2021190535 @default.
• W2082085050 cites W2024283568 @default.
• W2082085050 cites W2025652514 @default.
• W2082085050 cites W2042296157 @default.
• W2082085050 cites W2046639226 @default.
• W2082085050 cites W2048929274 @default.
• W2082085050 cites W2049175933 @default.
• W2082085050 cites W2057472068 @default.
• W2082085050 cites W2059072211 @default.
• W2082085050 cites W2059162424 @default.
• W2082085050 cites W2076658638 @default.
• W2082085050 cites W2091218964 @default.
• W2082085050 cites W2091782041 @default.
• W2082085050 cites W2093205464 @default.
• W2082085050 cites W2095370567 @default.
• W2082085050 cites W2106801137 @default.
• W2082085050 cites W2108117584 @default.
• W2082085050 cites W2131051792 @default.
• W2082085050 cites W2145234707 @default.
• W2082085050 cites W2145727337 @default.
• W2082085050 cites W2150094420 @default.
• W2082085050 cites W2150415011 @default.
• W2082085050 cites W2153831418 @default.
• W2082085050 cites W2154625613 @default.
• W2082085050 cites W2169300762 @default.
• W2082085050 cites W2172200786 @default.
• W2082085050 doi "https://doi.org/10.1074/jbc.m110.155523" @default.
• W2082085050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024781" @default.
• W2082085050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21098481" @default.
• W2082085050 hasPublicationYear "2011" @default.
• W2082085050 type Work @default.
• W2082085050 sameAs 2082085050 @default.
• W2082085050 citedByCount "51" @default.
• W2082085050 countsByYear W20820850502012 @default.
• W2082085050 countsByYear W20820850502013 @default.
• W2082085050 countsByYear W20820850502014 @default.
• W2082085050 countsByYear W20820850502015 @default.
• W2082085050 countsByYear W20820850502016 @default.
• W2082085050 countsByYear W20820850502017 @default.
• W2082085050 countsByYear W20820850502018 @default.
• W2082085050 countsByYear W20820850502019 @default.
• W2082085050 countsByYear W20820850502020 @default.
• W2082085050 countsByYear W20820850502021 @default.
• W2082085050 countsByYear W20820850502022 @default.
• W2082085050 countsByYear W20820850502023 @default.
• W2082085050 crossrefType "journal-article" @default.
• W2082085050 hasAuthorship W2082085050A5061728715 @default.
• W2082085050 hasAuthorship W2082085050A5076361927 @default.
• W2082085050 hasAuthorship W2082085050A5080910218 @default.
• W2082085050 hasBestOaLocation W20820850501 @default.
• W2082085050 hasConcept C104317684 @default.
• W2082085050 hasConcept C105580179 @default.
• W2082085050 hasConcept C120504264 @default.
• W2082085050 hasConcept C149364088 @default.
• W2082085050 hasConcept C153911025 @default.
• W2082085050 hasConcept C196843134 @default.
• W2082085050 hasConcept C2776690073 @default.
• W2082085050 hasConcept C2778437423 @default.
• W2082085050 hasConcept C2779535977 @default.
• W2082085050 hasConcept C29537977 @default.
• W2082085050 hasConcept C39685955 @default.
• W2082085050 hasConcept C54355233 @default.
• W2082085050 hasConcept C86803240 @default.
• W2082085050 hasConcept C95444343 @default.
• W2082085050 hasConceptScore W2082085050C104317684 @default.
• W2082085050 hasConceptScore W2082085050C105580179 @default.
• W2082085050 hasConceptScore W2082085050C120504264 @default.
• W2082085050 hasConceptScore W2082085050C149364088 @default.
• W2082085050 hasConceptScore W2082085050C153911025 @default.
• W2082085050 hasConceptScore W2082085050C196843134 @default.
• W2082085050 hasConceptScore W2082085050C2776690073 @default.
• W2082085050 hasConceptScore W2082085050C2778437423 @default.
• W2082085050 hasConceptScore W2082085050C2779535977 @default.
• W2082085050 hasConceptScore W2082085050C29537977 @default.
• W2082085050 hasConceptScore W2082085050C39685955 @default.
• W2082085050 hasConceptScore W2082085050C54355233 @default.

• next