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• W2082092017 abstract "Polysialic acid (polySia) is expressed on the surface of neural cells, neuroinvasive bacterial cells and several tumor cells. PolySia chains attached to NCAM can influence both trans interactions between membranes of two cells and cis interactions. Here, we report on the involvement of phospholipids in regulation of membrane interactions by polySia. The pH at the surface of liposomes, specific molecular area of phosphatidylcholine molecules, phase transition of DPPC bilayers, cyclic voltammograms of BLMs, and electron micrographs of phosphatidylcholine vesicles were studied after addition of polysialic acid free in solution. The results indicate that polySia chains can associate with phosphatidylcholine bilayers, incorporate into the polar part of a phospholipid monolayer, modulate cis interactions between phosphatidylcholine molecules, and facilitate trans interactions between apposing phospholipid vesicles. These observations imply that polySia attached to NCAM or to lipids can behave similarly." @default.
• W2082092017 created "2016-06-24" @default.
• W2082092017 creator A5020949290 @default.
• W2082092017 creator A5036057953 @default.
• W2082092017 date "2010-03-01" @default.
• W2082092017 modified "2023-09-27" @default.
• W2082092017 title "Polysialic acid can mediate membrane interactions by interacting with phospholipids" @default.
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• W2082092017 doi "https://doi.org/10.1016/j.chemphyslip.2009.12.003" @default.
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