Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082092197> ?p ?o ?g. }
- W2082092197 endingPage "957" @default.
- W2082092197 startingPage "951" @default.
- W2082092197 abstract "Abstract Spruce budworm larvae ( Choristoneura fumiferana ) upon ingesting tebufenozide (RH‐5992) stop feeding and go into a precocious, incomplete molt, leading eventually to death. Like 20‐hydroxyecdysone (20E), tebufenozide also acts at the receptor level and transactivates the expression of up‐regulated genes but, because of its persistence, the down‐regulated genes that are normally expressed in the absence of 20E are not expressed. While tebufenozide is lepidopteran‐specific, an analog, RH‐5849, is effective on dipterans. This is reflected in the respective effects of the two compounds on Cf‐203 ( C. fumiferana ‐ 203), a lepidopteran cell line and Dm‐2 ( Drosophila melanogaster ‐ 2), a dipteran cell line. Cf‐203 cells accumulated [ 14 C]tebufenozide and expressed CHR3 ( Choristoneura hormone receptor 3), but Dm‐2 cells excluded the material and did not express DHR3 ( Drosophila hormone receptor 3). Using yeast ABC (ATP binding cassette) transporter mutants, we determined that PDR5 (pleiotropic drug resistance 5) was responsible for the exclusion. We discovered recently that older instars of the white‐marked tussock moth ( Orgyia leucostigma ) are resistant to tebufenozide, perhaps as a result of such an exclusion system. We are currently cloning PDR5 (pleiotropic drug resistance 5), which is an essential step in studying the resistance mechanism. © 2001 Society of Chemical Industry" @default.
- W2082092197 created "2016-06-24" @default.
- W2082092197 creator A5003104749 @default.
- W2082092197 creator A5007226690 @default.
- W2082092197 creator A5012095912 @default.
- W2082092197 creator A5024606277 @default.
- W2082092197 creator A5062841591 @default.
- W2082092197 creator A5068632932 @default.
- W2082092197 creator A5085311231 @default.
- W2082092197 creator A5085917281 @default.
- W2082092197 creator A5090970931 @default.
- W2082092197 creator A5034000321 @default.
- W2082092197 date "2001-09-05" @default.
- W2082092197 modified "2023-10-18" @default.
- W2082092197 title "Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it" @default.
- W2082092197 cites W1006064478 @default.
- W2082092197 cites W1007847060 @default.
- W2082092197 cites W10979216 @default.
- W2082092197 cites W1511297544 @default.
- W2082092197 cites W1597247843 @default.
- W2082092197 cites W1965490357 @default.
- W2082092197 cites W1973782344 @default.
- W2082092197 cites W1987512186 @default.
- W2082092197 cites W1988823770 @default.
- W2082092197 cites W1994585631 @default.
- W2082092197 cites W2015803028 @default.
- W2082092197 cites W2016939288 @default.
- W2082092197 cites W2019294148 @default.
- W2082092197 cites W2024459655 @default.
- W2082092197 cites W2030170025 @default.
- W2082092197 cites W2030571034 @default.
- W2082092197 cites W2037618844 @default.
- W2082092197 cites W2039961170 @default.
- W2082092197 cites W2047789204 @default.
- W2082092197 cites W2072661096 @default.
- W2082092197 cites W2077449856 @default.
- W2082092197 cites W2078530629 @default.
- W2082092197 cites W2079435265 @default.
- W2082092197 cites W2089712805 @default.
- W2082092197 cites W2092630842 @default.
- W2082092197 cites W2097666362 @default.
- W2082092197 cites W2136267625 @default.
- W2082092197 cites W2139345033 @default.
- W2082092197 cites W2148859347 @default.
- W2082092197 cites W2149662691 @default.
- W2082092197 cites W2169181847 @default.
- W2082092197 cites W2174964781 @default.
- W2082092197 cites W4294216491 @default.
- W2082092197 doi "https://doi.org/10.1002/ps.377" @default.
- W2082092197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11695189" @default.
- W2082092197 hasPublicationYear "2001" @default.
- W2082092197 type Work @default.
- W2082092197 sameAs 2082092197 @default.
- W2082092197 citedByCount "52" @default.
- W2082092197 countsByYear W20820921972012 @default.
- W2082092197 countsByYear W20820921972014 @default.
- W2082092197 countsByYear W20820921972015 @default.
- W2082092197 countsByYear W20820921972016 @default.
- W2082092197 countsByYear W20820921972018 @default.
- W2082092197 countsByYear W20820921972019 @default.
- W2082092197 countsByYear W20820921972020 @default.
- W2082092197 countsByYear W20820921972021 @default.
- W2082092197 countsByYear W20820921972022 @default.
- W2082092197 crossrefType "journal-article" @default.
- W2082092197 hasAuthorship W2082092197A5003104749 @default.
- W2082092197 hasAuthorship W2082092197A5007226690 @default.
- W2082092197 hasAuthorship W2082092197A5012095912 @default.
- W2082092197 hasAuthorship W2082092197A5024606277 @default.
- W2082092197 hasAuthorship W2082092197A5034000321 @default.
- W2082092197 hasAuthorship W2082092197A5062841591 @default.
- W2082092197 hasAuthorship W2082092197A5068632932 @default.
- W2082092197 hasAuthorship W2082092197A5085311231 @default.
- W2082092197 hasAuthorship W2082092197A5085917281 @default.
- W2082092197 hasAuthorship W2082092197A5090970931 @default.
- W2082092197 hasConcept C104317684 @default.
- W2082092197 hasConcept C109130350 @default.
- W2082092197 hasConcept C2777180181 @default.
- W2082092197 hasConcept C2779324052 @default.
- W2082092197 hasConcept C54355233 @default.
- W2082092197 hasConcept C63932345 @default.
- W2082092197 hasConcept C86339819 @default.
- W2082092197 hasConcept C86803240 @default.
- W2082092197 hasConcept C98274493 @default.
- W2082092197 hasConceptScore W2082092197C104317684 @default.
- W2082092197 hasConceptScore W2082092197C109130350 @default.
- W2082092197 hasConceptScore W2082092197C2777180181 @default.
- W2082092197 hasConceptScore W2082092197C2779324052 @default.
- W2082092197 hasConceptScore W2082092197C54355233 @default.
- W2082092197 hasConceptScore W2082092197C63932345 @default.
- W2082092197 hasConceptScore W2082092197C86339819 @default.
- W2082092197 hasConceptScore W2082092197C86803240 @default.
- W2082092197 hasConceptScore W2082092197C98274493 @default.
- W2082092197 hasIssue "10" @default.
- W2082092197 hasLocation W20820921971 @default.
- W2082092197 hasLocation W20820921972 @default.
- W2082092197 hasOpenAccess W2082092197 @default.
- W2082092197 hasPrimaryLocation W20820921971 @default.
- W2082092197 hasRelatedWork W1974136230 @default.