Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082094554> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2082094554 endingPage "3217" @default.
- W2082094554 startingPage "3213" @default.
- W2082094554 abstract "Prolonged opioid treatment of HEK 293 cells expressing opioid receptors are known to induce adenylyl cyclase supersensitization, a process that requires pertussis toxin (PTX)-sensitive G(i/o) proteins. Here, the role of Gi2 in adenylyl cyclase supersensitization was investigated. A PTX-insensitive G alpha(i2)/z chimera was stably co-expressed with mu-, kappa- or delta-opioid receptors in HEK 293 cells. Functional coupling of G alpha(i2)/z to the opioid receptors was demonstrated by opioid-induced inhibition of adenylyl cyclase and stimulation of ERK1/2 phosphorylation in PTX-treated cells. Chronic opioid treatment of each cell line led to adenylyl cyclase supersensitization but this response was blocked by PTX. Our results demonstrated that although PTX-sensitive G proteins are obligatory for opioid-induced adenylyl cyclase supersensitization, Gi2 alone was insufficient to mediate this response." @default.
- W2082094554 created "2016-06-24" @default.
- W2082094554 creator A5074242872 @default.
- W2082094554 creator A5075059194 @default.
- W2082094554 date "2000-09-01" @default.
- W2082094554 modified "2023-10-03" @default.
- W2082094554 title "Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization" @default.
- W2082094554 cites W1976551644 @default.
- W2082094554 cites W1980605502 @default.
- W2082094554 cites W2003492314 @default.
- W2082094554 cites W2052191785 @default.
- W2082094554 cites W2087723846 @default.
- W2082094554 cites W2105080299 @default.
- W2082094554 cites W2218756952 @default.
- W2082094554 doi "https://doi.org/10.1097/00001756-200009280-00033" @default.
- W2082094554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11043551" @default.
- W2082094554 hasPublicationYear "2000" @default.
- W2082094554 type Work @default.
- W2082094554 sameAs 2082094554 @default.
- W2082094554 citedByCount "12" @default.
- W2082094554 countsByYear W20820945542012 @default.
- W2082094554 countsByYear W20820945542013 @default.
- W2082094554 countsByYear W20820945542015 @default.
- W2082094554 crossrefType "journal-article" @default.
- W2082094554 hasAuthorship W2082094554A5074242872 @default.
- W2082094554 hasAuthorship W2082094554A5075059194 @default.
- W2082094554 hasConcept C126322002 @default.
- W2082094554 hasConcept C134018914 @default.
- W2082094554 hasConcept C170493617 @default.
- W2082094554 hasConcept C176303035 @default.
- W2082094554 hasConcept C185592680 @default.
- W2082094554 hasConcept C24998067 @default.
- W2082094554 hasConcept C2751546 @default.
- W2082094554 hasConcept C2779178603 @default.
- W2082094554 hasConcept C2779886867 @default.
- W2082094554 hasConcept C2781063702 @default.
- W2082094554 hasConcept C49773422 @default.
- W2082094554 hasConcept C69101867 @default.
- W2082094554 hasConcept C71924100 @default.
- W2082094554 hasConcept C80631254 @default.
- W2082094554 hasConcept C86803240 @default.
- W2082094554 hasConcept C98274493 @default.
- W2082094554 hasConceptScore W2082094554C126322002 @default.
- W2082094554 hasConceptScore W2082094554C134018914 @default.
- W2082094554 hasConceptScore W2082094554C170493617 @default.
- W2082094554 hasConceptScore W2082094554C176303035 @default.
- W2082094554 hasConceptScore W2082094554C185592680 @default.
- W2082094554 hasConceptScore W2082094554C24998067 @default.
- W2082094554 hasConceptScore W2082094554C2751546 @default.
- W2082094554 hasConceptScore W2082094554C2779178603 @default.
- W2082094554 hasConceptScore W2082094554C2779886867 @default.
- W2082094554 hasConceptScore W2082094554C2781063702 @default.
- W2082094554 hasConceptScore W2082094554C49773422 @default.
- W2082094554 hasConceptScore W2082094554C69101867 @default.
- W2082094554 hasConceptScore W2082094554C71924100 @default.
- W2082094554 hasConceptScore W2082094554C80631254 @default.
- W2082094554 hasConceptScore W2082094554C86803240 @default.
- W2082094554 hasConceptScore W2082094554C98274493 @default.
- W2082094554 hasIssue "14" @default.
- W2082094554 hasLocation W20820945541 @default.
- W2082094554 hasLocation W20820945542 @default.
- W2082094554 hasOpenAccess W2082094554 @default.
- W2082094554 hasPrimaryLocation W20820945541 @default.
- W2082094554 hasRelatedWork W1972037087 @default.
- W2082094554 hasRelatedWork W1996177010 @default.
- W2082094554 hasRelatedWork W2009650171 @default.
- W2082094554 hasRelatedWork W2022696945 @default.
- W2082094554 hasRelatedWork W2045452477 @default.
- W2082094554 hasRelatedWork W2058724065 @default.
- W2082094554 hasRelatedWork W2079521776 @default.
- W2082094554 hasRelatedWork W2082094554 @default.
- W2082094554 hasRelatedWork W2161735622 @default.
- W2082094554 hasRelatedWork W2187040817 @default.
- W2082094554 hasVolume "11" @default.
- W2082094554 isParatext "false" @default.
- W2082094554 isRetracted "false" @default.
- W2082094554 magId "2082094554" @default.
- W2082094554 workType "article" @default.