FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082096237> ?p ?o ?g. }

• W2082096237 endingPage "568" @default.
• W2082096237 startingPage "553" @default.
• W2082096237 abstract "Alphavirus vectors have emerged as a strategy for the development of cancer vaccines and gene therapy applications. The availability of a new packaging cell line (PCL), which is capable of generating alphavirus replicon particles without contamination from replication-competent virus, has advanced the field of vaccine development. This replication-defective vaccine vector has potential advantages over naked nucleic acid vaccines, such as increased efficiency of gene delivery and large-scale production. We have developed a new strategy to enhance nucleic acid vaccine potency by linking VP22, a herpes simplex virus type 1 (HSV-1) tegument protein, to a model antigen. This strategy facilitated the spread of linked E7 antigen to neighboring cells. In this study, we created a recombinant Sindbis virus (SIN)-based replicon particle encoding VP22 linked to a model tumor antigen, human papillomavirus type 16 (HPV-16) E7, using a stable SIN PCL. The linkage of VP22 to E7 in these SIN replicon particles resulted in a significant increase in the number of E7-specific CD8(+) T cell precursors and a strong antitumor effect against E7-expressing tumors in vaccinated C57BL/6 mice relative to wild-type E7 SIN replicon particles. Furthermore, a head-to-head comparison of VP22-E7-containing naked DNA, naked RNA replicons, or RNA replicon particle vaccines indicated that SINrep5-VP22/E7 replicon particles generated the most potent therapeutic antitumor effect. Our results indicated that the VP22 strategy used in the context of SIN replicon particles may facilitate the generation of a highly effective vaccine for widespread immunization." @default.
• W2082096237 created "2016-06-24" @default.
• W2082096237 creator A5004703584 @default.
• W2082096237 creator A5007376349 @default.
• W2082096237 creator A5009004874 @default.
• W2082096237 creator A5018402939 @default.
• W2082096237 creator A5049874307 @default.
• W2082096237 creator A5051921899 @default.
• W2082096237 creator A5062803843 @default.
• W2082096237 creator A5064814823 @default.
• W2082096237 creator A5090305166 @default.
• W2082096237 date "2002-03-01" @default.
• W2082096237 modified "2023-10-18" @default.
• W2082096237 title "Cancer Immunotherapy Using Sindbis Virus Replicon Particles Encoding a VP22–Antigen Fusion" @default.
• W2082096237 cites W1535836957 @default.
• W2082096237 cites W1561591381 @default.
• W2082096237 cites W1751493734 @default.
• W2082096237 cites W1897775719 @default.
• W2082096237 cites W1975836300 @default.
• W2082096237 cites W1976822357 @default.
• W2082096237 cites W1978146796 @default.
• W2082096237 cites W1979750215 @default.
• W2082096237 cites W1980195265 @default.
• W2082096237 cites W1988136894 @default.
• W2082096237 cites W2002301242 @default.
• W2082096237 cites W2028303536 @default.
• W2082096237 cites W2043115431 @default.
• W2082096237 cites W2044881787 @default.
• W2082096237 cites W2053849689 @default.
• W2082096237 cites W2059483129 @default.
• W2082096237 cites W2062078150 @default.
• W2082096237 cites W2065810164 @default.
• W2082096237 cites W2083155294 @default.
• W2082096237 cites W2092438678 @default.
• W2082096237 cites W2105558735 @default.
• W2082096237 cites W2119651987 @default.
• W2082096237 cites W2120403825 @default.
• W2082096237 cites W2129192681 @default.
• W2082096237 cites W2158647190 @default.
• W2082096237 cites W2172163675 @default.
• W2082096237 cites W2312653119 @default.
• W2082096237 cites W4232596502 @default.
• W2082096237 cites W4244541510 @default.
• W2082096237 doi "https://doi.org/10.1089/10430340252809847" @default.
• W2082096237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11874633" @default.
• W2082096237 hasPublicationYear "2002" @default.
• W2082096237 type Work @default.
• W2082096237 sameAs 2082096237 @default.
• W2082096237 citedByCount "105" @default.
• W2082096237 countsByYear W20820962372012 @default.
• W2082096237 countsByYear W20820962372013 @default.
• W2082096237 countsByYear W20820962372014 @default.
• W2082096237 countsByYear W20820962372015 @default.
• W2082096237 countsByYear W20820962372016 @default.
• W2082096237 countsByYear W20820962372017 @default.
• W2082096237 countsByYear W20820962372018 @default.
• W2082096237 countsByYear W20820962372019 @default.
• W2082096237 countsByYear W20820962372020 @default.
• W2082096237 countsByYear W20820962372021 @default.
• W2082096237 crossrefType "journal-article" @default.
• W2082096237 hasAuthorship W2082096237A5004703584 @default.
• W2082096237 hasAuthorship W2082096237A5007376349 @default.
• W2082096237 hasAuthorship W2082096237A5009004874 @default.
• W2082096237 hasAuthorship W2082096237A5018402939 @default.
• W2082096237 hasAuthorship W2082096237A5049874307 @default.
• W2082096237 hasAuthorship W2082096237A5051921899 @default.
• W2082096237 hasAuthorship W2082096237A5062803843 @default.
• W2082096237 hasAuthorship W2082096237A5064814823 @default.
• W2082096237 hasAuthorship W2082096237A5090305166 @default.
• W2082096237 hasConcept C104317684 @default.
• W2082096237 hasConcept C153911025 @default.
• W2082096237 hasConcept C159047783 @default.
• W2082096237 hasConcept C18103114 @default.
• W2082096237 hasConcept C22744801 @default.
• W2082096237 hasConcept C2522874641 @default.
• W2082096237 hasConcept C2776387124 @default.
• W2082096237 hasConcept C2777343345 @default.
• W2082096237 hasConcept C2777474056 @default.
• W2082096237 hasConcept C40767141 @default.
• W2082096237 hasConcept C54355233 @default.
• W2082096237 hasConcept C67705224 @default.
• W2082096237 hasConcept C86803240 @default.
• W2082096237 hasConceptScore W2082096237C104317684 @default.
• W2082096237 hasConceptScore W2082096237C153911025 @default.
• W2082096237 hasConceptScore W2082096237C159047783 @default.
• W2082096237 hasConceptScore W2082096237C18103114 @default.
• W2082096237 hasConceptScore W2082096237C22744801 @default.
• W2082096237 hasConceptScore W2082096237C2522874641 @default.
• W2082096237 hasConceptScore W2082096237C2776387124 @default.
• W2082096237 hasConceptScore W2082096237C2777343345 @default.
• W2082096237 hasConceptScore W2082096237C2777474056 @default.
• W2082096237 hasConceptScore W2082096237C40767141 @default.
• W2082096237 hasConceptScore W2082096237C54355233 @default.
• W2082096237 hasConceptScore W2082096237C67705224 @default.
• W2082096237 hasConceptScore W2082096237C86803240 @default.
• W2082096237 hasIssue "4" @default.
• W2082096237 hasLocation W20820962371 @default.
• W2082096237 hasLocation W20820962372 @default.

• next