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- W2082100090 abstract "Purpose To compare the efficacy of neovascular AMD(NAMD) treatment options by monthly Lucentis(L)(monotherapy), combination therapy utilizing RF-PDT(P), and Lucentis combined with Kenalog(LK).Methods IRB-approved retrospective chart review of therapies administered only as-needed over 20 months. Inclusion criteria: active primary/recurrent subfoveal or juxtafoveal CNV (all types); Snellen BCVA ≥20/400. Exclusion criteria: f/u <3 months or noncompliance; subfoveal atrophy/fibrosis. Kenalog offered with Lucentis when active PED or subretinal fibrosis threatening fovea. RF-PDT combined with Avastin ± Kenalog(PA±K) or Kenalog alone(PK). Primary outcome measure: mean change in Snellen VA from baseline at last f/u. Secondary outcome measures: incidence of moderate/severe VA change; resolution of leakage; treatment-free interval.Results 21 eyes received L; 16 eyes LK; 10 eyes RF-PDT (5 PA±K; 5 PK). Mean f/u was 8.8 (range 3–18) months. At last f/u, mean Snellen VA for L improved -0.25; RF-PDT remained stable +0.06 overall (although PA±K improved -0.135; PK worsened +0.27); LK worsened +0.13 logMAR units (p=0.02 for L vs. LK). VA loss PA±K>LK>PK, occurring 91%, 80%, 75%, 60%, respectively. 14% L gained ≥30 letters. 20% PK lost ≥30 letters. Leakage resolved greater for L>PA±K>LK>PK, occurring 86%, 80%, 69%, 40%, respectively.Conclusion At intermediate-term f/u, Lucentis monotherapy administered only as-needed had results similar to larger studies and was the most effective in maintaining or improving VA in NAMD. Lucentis monotherapy had the greatest leakage resolution and treatment-free interval. RF-PDT with Avastin was more effective than with Kenalog alone. Kenalog supplementation to Lucentis unlikely provided added benefit." @default.
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- W2082100090 date "2008-09-04" @default.
- W2082100090 modified "2023-09-27" @default.
- W2082100090 title "Comparison of Lucentis monotherapy vs. combination therapy for neovascular AMD" @default.
- W2082100090 doi "https://doi.org/10.1111/j.1755-3768.2008.6448.x" @default.
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