FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082100220> ?p ?o ?g. }

• W2082100220 endingPage "1141" @default.
• W2082100220 startingPage "1135" @default.
• W2082100220 abstract "Stereoselective metabolism of 9-methylanthracene (9-M-A), 9-hydroxymethylanthracene (9-OHM-A) and 9,10-dimethylanthracene (9,10-DM-A) by liver microsomes from untreated rats, and from rats pretreated with either 3-methylcholanthrene or phenobarbital was studied. The metabolites were separated by h.p.l.c. and characterized by analysis of the u.v.-visible, mass and n.m.r. spectral data and compared to published spectral data. The identified trans-dihydrodiol metabolites were 9-M-A trans-1,2- and 3,4-dihydrodiols, 9-OHM-A trans-1,2- and 3,4-dihydrodiols, and 9,10-DM-A trans-1,2-dihydrodiol. The absolute configuration and optical (enantiomeric) purity of the trans-dihydrodiol metabolites were determined. In order to assist in determining the absolute configuration of these trans-dihydrodiols, metabolism of 9-bromoanthracene by liver microsomes of rats pretreated with 3-methylcholanthrene was performed and its trans-1,2- and 3,4-dihydrodiol metabolites were determined to both possess an R,R absolute configuration. Absolute configurations of the trans-dihydrodiol metabolites of 9-methylanthracene, 9-hydroxymethylanthracene and 9,10-dimethylanthracene were then determined by comparison of their CD spectra with those of anthracene 1R,2R-dihydrodiol or 9-bromoanthracene 1R,2R-dihydrodiol. The optical purities of the trans-dihydrodiol metabolites were determined by analysis of the chiral stationary phase h.p.l.c. profiles of the dihydrodiols or their corresponding tetrahydrodiol derivatives. The results indicated that the R,R enantiomers were the predominant products and that liver microsomes of rats pretreated with 3-methylcholanthrene exhibited much higher stereoselectivity than the liver microsomes of untreated rats or rats pretreated with phenobarbital in the formation of trans-dihydrodiols from anthracene, 9-methylanthracene, 9-hydroxymethylanthracene and 9,10-dimethylanthracene. The methyl and hydroxymethyl substituents slightly decreased the stereoselectivity of the trans-dihydrodiol formation." @default.
• W2082100220 created "2016-06-24" @default.
• W2082100220 creator A5021275406 @default.
• W2082100220 creator A5069374770 @default.
• W2082100220 date "1986-01-01" @default.
• W2082100220 modified "2023-09-23" @default.
• W2082100220 title "Stereoselective metabolism of 9-methyl-, 9-hydroxymethyl- and 9,10-dimethylanthracenes: absolute configurations and optical purities of <i>trans</i>-dihydrodiol metabolites" @default.
• W2082100220 doi "https://doi.org/10.1093/carcin/7.7.1135" @default.
• W2082100220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3719909" @default.
• W2082100220 hasPublicationYear "1986" @default.
• W2082100220 type Work @default.
• W2082100220 sameAs 2082100220 @default.
• W2082100220 citedByCount "16" @default.
• W2082100220 countsByYear W20821002202016 @default.
• W2082100220 countsByYear W20821002202023 @default.
• W2082100220 crossrefType "journal-article" @default.
• W2082100220 hasAuthorship W2082100220A5021275406 @default.
• W2082100220 hasAuthorship W2082100220A5069374770 @default.
• W2082100220 hasConcept C161790260 @default.
• W2082100220 hasConcept C181647583 @default.
• W2082100220 hasConcept C185592680 @default.
• W2082100220 hasConcept C202751555 @default.
• W2082100220 hasConcept C25170562 @default.
• W2082100220 hasConcept C2777477808 @default.
• W2082100220 hasConcept C2780591741 @default.
• W2082100220 hasConcept C43617362 @default.
• W2082100220 hasConcept C486523 @default.
• W2082100220 hasConcept C55493867 @default.
• W2082100220 hasConcept C62231903 @default.
• W2082100220 hasConcept C71240020 @default.
• W2082100220 hasConcept C87644729 @default.
• W2082100220 hasConceptScore W2082100220C161790260 @default.
• W2082100220 hasConceptScore W2082100220C181647583 @default.
• W2082100220 hasConceptScore W2082100220C185592680 @default.
• W2082100220 hasConceptScore W2082100220C202751555 @default.
• W2082100220 hasConceptScore W2082100220C25170562 @default.
• W2082100220 hasConceptScore W2082100220C2777477808 @default.
• W2082100220 hasConceptScore W2082100220C2780591741 @default.
• W2082100220 hasConceptScore W2082100220C43617362 @default.
• W2082100220 hasConceptScore W2082100220C486523 @default.
• W2082100220 hasConceptScore W2082100220C55493867 @default.
• W2082100220 hasConceptScore W2082100220C62231903 @default.
• W2082100220 hasConceptScore W2082100220C71240020 @default.
• W2082100220 hasConceptScore W2082100220C87644729 @default.
• W2082100220 hasIssue "7" @default.
• W2082100220 hasLocation W20821002201 @default.
• W2082100220 hasLocation W20821002202 @default.
• W2082100220 hasOpenAccess W2082100220 @default.
• W2082100220 hasPrimaryLocation W20821002201 @default.
• W2082100220 hasRelatedWork W1837220925 @default.
• W2082100220 hasRelatedWork W1966967179 @default.
• W2082100220 hasRelatedWork W1989575556 @default.
• W2082100220 hasRelatedWork W2011071029 @default.
• W2082100220 hasRelatedWork W2029966651 @default.
• W2082100220 hasRelatedWork W2099984455 @default.
• W2082100220 hasRelatedWork W2418643629 @default.
• W2082100220 hasRelatedWork W2444015705 @default.
• W2082100220 hasRelatedWork W2626407967 @default.
• W2082100220 hasRelatedWork W2951541015 @default.
• W2082100220 hasVolume "7" @default.
• W2082100220 isParatext "false" @default.
• W2082100220 isRetracted "false" @default.
• W2082100220 magId "2082100220" @default.
• W2082100220 workType "article" @default.