Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082104199> ?p ?o ?g. }
- W2082104199 endingPage "3637" @default.
- W2082104199 startingPage "3637" @default.
- W2082104199 abstract "The design, synthesis, and characterization of novel cavitand-based hetero-TASPs, TASPs having different peptide sequences within one bundle, are described. Three families of hetero-TASPs were designed: the LG3/LG2 family (different linker lengths), LG3/AG3 family (altering helix hydrophobicity), and the LG3/LG2C family (anti-parallel caviteins). These first generation hetero-TASPs were found to be α-helical, stable towards guanidine hydrochloride, and monomeric in solution. The LG3/LG2 caviteins exhibited primarily native-like properties. The remaining hetero-TASP families were found to exhibit less dispersion and broader signals in the amide regions of their 1H NMR spectra than their respective reference caviteins. The success in the design of the LG3/LG2 hetero-TASPs suggests that subsequent hetero-TASPs may have potential to manifest superior native-like structure compared with homo-TASPs, and refinement of the linker and peptide sequences may accomplish this goal." @default.
- W2082104199 created "2016-06-24" @default.
- W2082104199 creator A5068064655 @default.
- W2082104199 creator A5081454326 @default.
- W2082104199 date "2007-01-01" @default.
- W2082104199 modified "2023-10-14" @default.
- W2082104199 title "The design, synthesis, and characterization of the first cavitand-based de novo hetero-template-assembled synthetic proteins (Hetero-TASPs)" @default.
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- W2082104199 doi "https://doi.org/10.1039/b711869d" @default.