FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082105417> ?p ?o ?g. }

• W2082105417 endingPage "2546" @default.
• W2082105417 startingPage "2540" @default.
• W2082105417 abstract "Recurrence of acute lymphoblastic leukemia (ALL) in the central nervous system (CNS) confers a poor prognosis, although to the authors' knowledge, only a few studies have analyzed this issue in adults. For the current study, the authors analyzed the frequency, predictive factors, and prognosis of CNS involvement and recurrence in adult patients with ALL who did not receive cranial irradiation for CNS prophylaxis. Four hundred sixty-seven adult patients (age ≥15 years) with ALL were treated on 4 protocols: ALL-89 (standard-risk and high-risk ALL; n = 108 patients), ALL-93 (high-risk ALL; n = 222 patients), ALL-96 (standard-risk ALL; n = 84 patients), and ALL3-97 (Burkitt leukemia; n = 53 patients). CNS prophylaxis consisted of intrathecal methotrexate, cytarabine, and hydrocortisone together with high-dose systemic methotrexate and cytarabine. The mean age (± standard deviation) was 33 years (± 16 years), and 272 patients were males. ALL subtypes included an early pre-B phenotype (15%), a common phenotype (45%), a pre-B phenotype (5%), a mature B phenotype (11%), and a T phenotype (24%). CNS involvement at diagnosis was observed in 18 patients (3.9%). Of 159 recurrences, 22 occurred (5.8%) in the CNS (14 isolated and 8 combined). A lactate dehydrogenase level >1000 U/L was the only factor associated with the risk of CNS recurrence. A complete remission was attained in 7 of 22 patients (32%). The median overall survival after recurrence was 0.7 years for patients with isolated CNS recurrence, 0.13 years for patients with combined recurrence, and 0.41 years for patients with bone marrow recurrence (P = .11). The only 2 survivors underwent stem cell transplantation. The frequency of CNS recurrence in adult patients with ALL who do not receive radiotherapy for CNS prophylaxis was similar to the frequency observed in protocols that included cranial irradiation. A lactate dehydrogenase value >1000 U/L was the only factor found to be associated with CNS recurrence. The prognosis for patients who develop CNS recurrence is poor, identical to that for patients who develop bone marrow recurrence. Cancer 2006. © 2006 American Cancer Society." @default.
• W2082105417 created "2016-06-24" @default.
• W2082105417 creator A5008564951 @default.
• W2082105417 creator A5018422609 @default.
• W2082105417 creator A5019771921 @default.
• W2082105417 creator A5021872040 @default.
• W2082105417 creator A5024617467 @default.
• W2082105417 creator A5054706356 @default.
• W2082105417 creator A5054952877 @default.
• W2082105417 creator A5078153093 @default.
• W2082105417 creator A5084354003 @default.
• W2082105417 creator A5084749075 @default.
• W2082105417 date "2006-01-01" @default.
• W2082105417 modified "2023-10-17" @default.
• W2082105417 title "Central nervous system recurrence in adult patients with acute lymphoblastic leukemia" @default.
• W2082105417 cites W11202050 @default.
• W2082105417 cites W121090805 @default.
• W2082105417 cites W152381011 @default.
• W2082105417 cites W1969482750 @default.
• W2082105417 cites W1993917421 @default.
• W2082105417 cites W2001299334 @default.
• W2082105417 cites W2003853210 @default.
• W2082105417 cites W2058491187 @default.
• W2082105417 cites W2059504602 @default.
• W2082105417 cites W2060974470 @default.
• W2082105417 cites W2070404798 @default.
• W2082105417 cites W2076426515 @default.
• W2082105417 cites W2107685938 @default.
• W2082105417 cites W2109279774 @default.
• W2082105417 cites W2138575422 @default.
• W2082105417 cites W2166295047 @default.
• W2082105417 cites W2170012309 @default.
• W2082105417 cites W2172671442 @default.
• W2082105417 cites W2310979785 @default.
• W2082105417 cites W2321645542 @default.
• W2082105417 cites W2335926318 @default.
• W2082105417 cites W2587970063 @default.
• W2082105417 cites W4250953352 @default.
• W2082105417 cites W4293241248 @default.
• W2082105417 cites W4298434897 @default.
• W2082105417 cites W7217595 @default.
• W2082105417 doi "https://doi.org/10.1002/cncr.21948" @default.
• W2082105417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16700036" @default.
• W2082105417 hasPublicationYear "2006" @default.
• W2082105417 type Work @default.
• W2082105417 sameAs 2082105417 @default.
• W2082105417 citedByCount "58" @default.
• W2082105417 countsByYear W20821054172012 @default.
• W2082105417 countsByYear W20821054172013 @default.
• W2082105417 countsByYear W20821054172014 @default.
• W2082105417 countsByYear W20821054172015 @default.
• W2082105417 countsByYear W20821054172016 @default.
• W2082105417 countsByYear W20821054172017 @default.
• W2082105417 countsByYear W20821054172018 @default.
• W2082105417 countsByYear W20821054172019 @default.
• W2082105417 countsByYear W20821054172020 @default.
• W2082105417 countsByYear W20821054172021 @default.
• W2082105417 countsByYear W20821054172022 @default.
• W2082105417 countsByYear W20821054172023 @default.
• W2082105417 crossrefType "journal-article" @default.
• W2082105417 hasAuthorship W2082105417A5008564951 @default.
• W2082105417 hasAuthorship W2082105417A5018422609 @default.
• W2082105417 hasAuthorship W2082105417A5019771921 @default.
• W2082105417 hasAuthorship W2082105417A5021872040 @default.
• W2082105417 hasAuthorship W2082105417A5024617467 @default.
• W2082105417 hasAuthorship W2082105417A5054706356 @default.
• W2082105417 hasAuthorship W2082105417A5054952877 @default.
• W2082105417 hasAuthorship W2082105417A5078153093 @default.
• W2082105417 hasAuthorship W2082105417A5084354003 @default.
• W2082105417 hasAuthorship W2082105417A5084749075 @default.
• W2082105417 hasBestOaLocation W20821054171 @default.
• W2082105417 hasConcept C126322002 @default.
• W2082105417 hasConcept C141071460 @default.
• W2082105417 hasConcept C2778041864 @default.
• W2082105417 hasConcept C2778397455 @default.
• W2082105417 hasConcept C2778461978 @default.
• W2082105417 hasConcept C2781059491 @default.
• W2082105417 hasConcept C2781107101 @default.
• W2082105417 hasConcept C2909962599 @default.
• W2082105417 hasConcept C529278444 @default.
• W2082105417 hasConcept C71924100 @default.
• W2082105417 hasConcept C90924648 @default.
• W2082105417 hasConceptScore W2082105417C126322002 @default.
• W2082105417 hasConceptScore W2082105417C141071460 @default.
• W2082105417 hasConceptScore W2082105417C2778041864 @default.
• W2082105417 hasConceptScore W2082105417C2778397455 @default.
• W2082105417 hasConceptScore W2082105417C2778461978 @default.
• W2082105417 hasConceptScore W2082105417C2781059491 @default.
• W2082105417 hasConceptScore W2082105417C2781107101 @default.
• W2082105417 hasConceptScore W2082105417C2909962599 @default.
• W2082105417 hasConceptScore W2082105417C529278444 @default.
• W2082105417 hasConceptScore W2082105417C71924100 @default.
• W2082105417 hasConceptScore W2082105417C90924648 @default.
• W2082105417 hasIssue "12" @default.
• W2082105417 hasLocation W20821054171 @default.
• W2082105417 hasLocation W20821054172 @default.
• W2082105417 hasOpenAccess W2082105417 @default.
• W2082105417 hasPrimaryLocation W20821054171 @default.

• next