Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082130211> ?p ?o ?g. }
- W2082130211 endingPage "940" @default.
- W2082130211 startingPage "925" @default.
- W2082130211 abstract "The constrained backbone torsion angle of a proline (Pro) residue has usually been invoked to explain its three-dimensional context in proteins. Here we show that specific interactions involving the pyrrolidine ring atoms also contribute to its location in a given secondary structure and its binding to another molecule. It is adept at participating in two rather non-conventional interactions, C–H⋯π and C–H⋯O. The geometry of interaction between the pyrrolidine and aromatic rings, vis-à-vis the occurrence of the C–H⋯π interactions has been elucidated. Some of the secondary structural elements stabilized by Pro–aromatic interactions are β-turns, where a Pro can interact with an adjacent aromatic residue, and in antiparallel β-sheet, where a Pro in an edge strand can interact with an aromatic residue in the adjacent strand at a non-hydrogen-bonded site. The C–H groups at the Cα and Cδ positions can form strong C–H⋯O interactions (as seen from the clustering of points) and such interactions involving a Pro residue at C′ position relative to an α-helix can cap the hydrogen bond forming potentials of the free carbonyl groups at the helix C terminus. Functionally important Pro residues occurring at the binding site of a protein almost invariably engage aromatic residues (with one of them being held by C–H⋯π interaction) from the partner molecule in the complex, and such aromatic residues are highly conserved during evolution." @default.
- W2082130211 created "2016-06-24" @default.
- W2082130211 creator A5000031273 @default.
- W2082130211 creator A5088368426 @default.
- W2082130211 date "2003-08-01" @default.
- W2082130211 modified "2023-10-17" @default.
- W2082130211 title "Stereospecific Interactions of Proline Residues in Protein Structures and Complexes" @default.
- W2082130211 cites W1532713936 @default.
- W2082130211 cites W1551351981 @default.
- W2082130211 cites W1583655086 @default.
- W2082130211 cites W1585344957 @default.
- W2082130211 cites W1748445510 @default.
- W2082130211 cites W1843397982 @default.
- W2082130211 cites W1965906560 @default.
- W2082130211 cites W1967582433 @default.
- W2082130211 cites W1969291218 @default.
- W2082130211 cites W1971251199 @default.
- W2082130211 cites W1974176847 @default.
- W2082130211 cites W1975898157 @default.
- W2082130211 cites W1976261939 @default.
- W2082130211 cites W1978892474 @default.
- W2082130211 cites W1985153601 @default.
- W2082130211 cites W1991494214 @default.
- W2082130211 cites W1993586059 @default.
- W2082130211 cites W1993870517 @default.
- W2082130211 cites W1996427305 @default.
- W2082130211 cites W2000430596 @default.
- W2082130211 cites W2004178884 @default.
- W2082130211 cites W2004360551 @default.
- W2082130211 cites W2005238994 @default.
- W2082130211 cites W2008708467 @default.
- W2082130211 cites W2008849781 @default.
- W2082130211 cites W2024610505 @default.
- W2082130211 cites W2025748454 @default.
- W2082130211 cites W2028231353 @default.
- W2082130211 cites W2041933909 @default.
- W2082130211 cites W2047572594 @default.
- W2082130211 cites W2048931419 @default.
- W2082130211 cites W2049695588 @default.
- W2082130211 cites W2051617312 @default.
- W2082130211 cites W2051654117 @default.
- W2082130211 cites W2051710717 @default.
- W2082130211 cites W2053721311 @default.
- W2082130211 cites W2054291744 @default.
- W2082130211 cites W2054607729 @default.
- W2082130211 cites W2056185103 @default.
- W2082130211 cites W2056770911 @default.
- W2082130211 cites W2062639699 @default.
- W2082130211 cites W2063475546 @default.
- W2082130211 cites W2071268775 @default.
- W2082130211 cites W2072788367 @default.
- W2082130211 cites W2074655761 @default.
- W2082130211 cites W2076541507 @default.
- W2082130211 cites W2076648189 @default.
- W2082130211 cites W2077895595 @default.
- W2082130211 cites W2080972330 @default.
- W2082130211 cites W2081359387 @default.
- W2082130211 cites W2084374650 @default.
- W2082130211 cites W2087883868 @default.
- W2082130211 cites W2089850443 @default.
- W2082130211 cites W2090570211 @default.
- W2082130211 cites W2090758881 @default.
- W2082130211 cites W2092006899 @default.
- W2082130211 cites W2100314081 @default.
- W2082130211 cites W2106315897 @default.
- W2082130211 cites W2106481565 @default.
- W2082130211 cites W2108176208 @default.
- W2082130211 cites W2109228802 @default.
- W2082130211 cites W2113671566 @default.
- W2082130211 cites W2115339329 @default.
- W2082130211 cites W2118270944 @default.
- W2082130211 cites W2121753315 @default.
- W2082130211 cites W2123395043 @default.
- W2082130211 cites W2123501118 @default.
- W2082130211 cites W2127582557 @default.
- W2082130211 cites W2130479394 @default.
- W2082130211 cites W2135572502 @default.
- W2082130211 cites W2135827613 @default.
- W2082130211 cites W2137991504 @default.
- W2082130211 cites W2138169197 @default.
- W2082130211 cites W2142757818 @default.
- W2082130211 cites W2144217620 @default.
- W2082130211 cites W2151769486 @default.
- W2082130211 cites W2154042308 @default.
- W2082130211 cites W2154918056 @default.
- W2082130211 cites W2157715218 @default.
- W2082130211 cites W2161149018 @default.
- W2082130211 cites W2161869841 @default.
- W2082130211 cites W2164450010 @default.
- W2082130211 cites W2165716111 @default.
- W2082130211 cites W2168211076 @default.
- W2082130211 cites W248588628 @default.
- W2082130211 cites W3047703793 @default.
- W2082130211 cites W4294326239 @default.
- W2082130211 doi "https://doi.org/10.1016/s0022-2836(03)00759-9" @default.
- W2082130211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12909019" @default.
- W2082130211 hasPublicationYear "2003" @default.
- W2082130211 type Work @default.