FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082133069> ?p ?o ?g. }

• W2082133069 endingPage "649" @default.
• W2082133069 startingPage "640" @default.
• W2082133069 abstract "Expression of hepatocyte growth factor (HGF) and its tyrosine kinase receptor, c-Met, is positively correlated with breast carcinoma progression. We found that in invasive and metastatic MTLn3 breast carcinoma cells, HGF stimulated both initial adhesion to and motility on the extracellular matrix (ECM) ligands laminin 1, type I collagen, and fibronectin. Next, analysis with function-perturbing antibodies showed that adhesion to the different ECM proteins was mediated through specific beta1 integrins. In MTLn3 cells, HGF induced rapid tyrosine phosphorylation and activation of both c-Met and focal adhesion kinase (FAK). Cell anchorage and adhesion to the ECM substrates was required for HGF-induced FAK activation, since HGF failed to trigger tyrosine phosphorylation of FAK in suspended cells. Our results provide evidence that the 2 signaling pathways, integrin/ECM and c-Met/HGF, cooperate synergistically to induce FAK activation in an adhesion-dependent manner, leading to enhanced cell adhesion and motility. Moreover, we found that a FRNK (the FAK-related non-kinase)-like molecule is expressed in MTLn3 cells. Since FRNK acts as a competitive inhibitor of FAK function, our results suggest that a FRNK-like protein could facilitate disassembly of focal adhesions and likely be responsible for the HGF-induced scattering and motility of MTLn3 cells." @default.
• W2082133069 created "2016-06-24" @default.
• W2082133069 creator A5027631631 @default.
• W2082133069 creator A5031672257 @default.
• W2082133069 date "1999-11-26" @default.
• W2082133069 modified "2023-09-26" @default.
• W2082133069 title "HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells" @default.
• W2082133069 cites W1551629532 @default.
• W2082133069 cites W1976628682 @default.
• W2082133069 cites W1997121235 @default.
• W2082133069 cites W1999515047 @default.
• W2082133069 cites W2018512891 @default.
• W2082133069 cites W2018672261 @default.
• W2082133069 cites W2028691987 @default.
• W2082133069 cites W2029231027 @default.
• W2082133069 cites W2033974104 @default.
• W2082133069 cites W2037619760 @default.
• W2082133069 cites W2044895358 @default.
• W2082133069 cites W2052626837 @default.
• W2082133069 cites W2075943246 @default.
• W2082133069 cites W2094283361 @default.
• W2082133069 cites W2139471842 @default.
• W2082133069 cites W2148849095 @default.
• W2082133069 cites W2199222029 @default.
• W2082133069 doi "https://doi.org/10.1002/(sici)1097-0215(19991126)83:5<640::aid-ijc13>3.0.co;2-d" @default.
• W2082133069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10521801" @default.
• W2082133069 hasPublicationYear "1999" @default.
• W2082133069 type Work @default.
• W2082133069 sameAs 2082133069 @default.
• W2082133069 citedByCount "61" @default.
• W2082133069 countsByYear W20821330692013 @default.
• W2082133069 countsByYear W20821330692014 @default.
• W2082133069 countsByYear W20821330692015 @default.
• W2082133069 countsByYear W20821330692017 @default.
• W2082133069 countsByYear W20821330692018 @default.
• W2082133069 countsByYear W20821330692019 @default.
• W2082133069 countsByYear W20821330692020 @default.
• W2082133069 countsByYear W20821330692021 @default.
• W2082133069 countsByYear W20821330692022 @default.
• W2082133069 crossrefType "journal-article" @default.
• W2082133069 hasAuthorship W2082133069A5027631631 @default.
• W2082133069 hasAuthorship W2082133069A5031672257 @default.
• W2082133069 hasConcept C101544691 @default.
• W2082133069 hasConcept C108391706 @default.
• W2082133069 hasConcept C11960822 @default.
• W2082133069 hasConcept C151166631 @default.
• W2082133069 hasConcept C16224149 @default.
• W2082133069 hasConcept C170493617 @default.
• W2082133069 hasConcept C178790620 @default.
• W2082133069 hasConcept C185592680 @default.
• W2082133069 hasConcept C189165786 @default.
• W2082133069 hasConcept C195687474 @default.
• W2082133069 hasConcept C2776165026 @default.
• W2082133069 hasConcept C2776996007 @default.
• W2082133069 hasConcept C2777553839 @default.
• W2082133069 hasConcept C2779814568 @default.
• W2082133069 hasConcept C42362537 @default.
• W2082133069 hasConcept C502942594 @default.
• W2082133069 hasConcept C55493867 @default.
• W2082133069 hasConcept C58207958 @default.
• W2082133069 hasConcept C62478195 @default.
• W2082133069 hasConcept C84416704 @default.
• W2082133069 hasConcept C85789140 @default.
• W2082133069 hasConcept C86492073 @default.
• W2082133069 hasConcept C86803240 @default.
• W2082133069 hasConcept C90934575 @default.
• W2082133069 hasConcept C95444343 @default.
• W2082133069 hasConcept C97029542 @default.
• W2082133069 hasConceptScore W2082133069C101544691 @default.
• W2082133069 hasConceptScore W2082133069C108391706 @default.
• W2082133069 hasConceptScore W2082133069C11960822 @default.
• W2082133069 hasConceptScore W2082133069C151166631 @default.
• W2082133069 hasConceptScore W2082133069C16224149 @default.
• W2082133069 hasConceptScore W2082133069C170493617 @default.
• W2082133069 hasConceptScore W2082133069C178790620 @default.
• W2082133069 hasConceptScore W2082133069C185592680 @default.
• W2082133069 hasConceptScore W2082133069C189165786 @default.
• W2082133069 hasConceptScore W2082133069C195687474 @default.
• W2082133069 hasConceptScore W2082133069C2776165026 @default.
• W2082133069 hasConceptScore W2082133069C2776996007 @default.
• W2082133069 hasConceptScore W2082133069C2777553839 @default.
• W2082133069 hasConceptScore W2082133069C2779814568 @default.
• W2082133069 hasConceptScore W2082133069C42362537 @default.
• W2082133069 hasConceptScore W2082133069C502942594 @default.
• W2082133069 hasConceptScore W2082133069C55493867 @default.
• W2082133069 hasConceptScore W2082133069C58207958 @default.
• W2082133069 hasConceptScore W2082133069C62478195 @default.
• W2082133069 hasConceptScore W2082133069C84416704 @default.
• W2082133069 hasConceptScore W2082133069C85789140 @default.
• W2082133069 hasConceptScore W2082133069C86492073 @default.
• W2082133069 hasConceptScore W2082133069C86803240 @default.
• W2082133069 hasConceptScore W2082133069C90934575 @default.
• W2082133069 hasConceptScore W2082133069C95444343 @default.
• W2082133069 hasConceptScore W2082133069C97029542 @default.
• W2082133069 hasIssue "5" @default.
• W2082133069 hasLocation W20821330691 @default.
• W2082133069 hasLocation W20821330692 @default.
• W2082133069 hasOpenAccess W2082133069 @default.

• next