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• W2082161010 abstract "In Brief Objective: To determine if an antecolic or a retrocolic duodenojejunostomy during pylorus-preserving pancreaticoduodenectomy (PpPD) was associated with the least incidence of delayed gastric emptying (DGE), in a prospective, randomized, controlled trial. Summary Background Data: The pathogenesis of DGE after PpPD has been speculated to be related to factors such as inflammation, ischemia, gastric atony, motilin levels, and type of surgical procedure. Previous retrospective studies have shown a lower incidence of DGE after antecolic duodenojejunostomy. A prospective trial is needed. Methods: Forty patients were enrolled in this trial between May 2002 and April 2004. Just before duodenojejunostomy during PpPD, the patients were randomly assigned to undergo either an antecolic or a retrocolic duodenojejunostomy. Results: DGE occurred in 5% of patients with the antecolic route for duodenojejunostomy versus 50% with the retrocolic route (P = 0.0014). Those with the antecolic route had a significantly shorter duration of postoperative nasogastric tube drainage than did those with the retrocolic route (4.2 days versus 18.9 days, respectively, P = 0.047). By postoperative day 14, all patients with the antecolic route could take solid foods, while only 55% (11 of 20) of the patients with the retrocolic route could take solid foods (P = 0.0007). The length of stay in the hospital was 28 days for the antecolic group versus 48 days for the retrocolic group (P = 0.018). Conclusions: Antecolic reconstruction for duodenojejunostomy during PpPD decreases postoperative morbidity and length of hospital stay by decreasing DGE. Our data suggest that PpPD with antecolic duodenojejunostomy is a safer operation. To investigate whether an antecolic route for duodenojejunostomy reconstruction reduced the incidence of delayed gastric emptying (DGE) after pylorus-preserving pancreaticoduodenectomy (PpPD), in a prospective, randomized, controlled trial. DGE occurred in 5% of patients with the antecolic route versus 50% after a retrocolic route for gastrointestinal reconstruction. Our prospective observations suggest that the antecolic route for gastrointestinal reconstruction decreases DGE and its inherent morbidity to make PpPD an even safer procedure." @default.
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• W2082161010 date "2006-03-01" @default.
• W2082161010 modified "2023-10-17" @default.
• W2082161010 title "Improvement of Delayed Gastric Emptying in Pylorus-Preserving Pancreaticoduodenectomy" @default.
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• W2082161010 doi "https://doi.org/10.1097/01.sla.0000201479.84934.ca" @default.
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