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- W2082165572 abstract "The protein coded by a bleomycin‐resistance gene ( ble ) cloned from producing actinomycetes was purified from a culture of a recombinant E.coli strain and its action on bleomycin was determined by in vitro assays. The protein binds reversibly in a one to one ratio to bleomycin which can no longer cleave DNA. The bleomycin resistance of cells harboring a ble gene could be accounted for by a sequestering effect of the bleomycin‐binding protein." @default.
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- W2082165572 date "1988-03-28" @default.
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- W2082165572 title "Bleomycin resistance conferred by a drug-binding protein" @default.
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- W2082165572 doi "https://doi.org/10.1016/0014-5793(88)80665-3" @default.
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