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- W2082183485 abstract "A series of 36 synthetic antimicrobial peptides containing unnatural amino acids were screened to determine their effectiveness to treat Enterococcus faecium, Staphylococcus aureus, Klebsiella pnemoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) pathogens, which are known to commonly infect chronic wounds. The primary amino acid sequences of these peptides incorporate either three or six dipeptide units consisting of the unnatural amino acids Tetrahydroisoquinolinecarboxylic acid (Tic) and Octahydroindolecarboxylic acid (Oic). The Tic-Oic dipeptide units are separated by SPACER amino acids with specific physicochemical properties that control how these peptides interact with bacterial cell membranes of different chemical compositions. These peptides exhibited minimum inhibitory concentrations (MIC) against these pathogens in the range from >100 to 6.25 μg/mL. The observed diversity of MIC values for these peptides against the various bacterial strains are consistent with our hypothesis that the complementarity of the physicochemical properties of the peptide and the lipid of the bacteria’s cell membrane determines the resulting antibacterial activity of the peptide." @default.
- W2082183485 created "2016-06-24" @default.
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- W2082183485 date "2013-01-01" @default.
- W2082183485 modified "2023-10-04" @default.
- W2082183485 title "Antimicrobial peptides containing unnatural amino acid exhibit potent bactericidal activity against ESKAPE pathogens" @default.
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- W2082183485 cites W1963606380 @default.
- W2082183485 cites W1968120681 @default.
- W2082183485 cites W1973742248 @default.
- W2082183485 cites W1976301815 @default.
- W2082183485 cites W1977241485 @default.
- W2082183485 cites W1978226795 @default.
- W2082183485 cites W1980883669 @default.
- W2082183485 cites W1981196057 @default.
- W2082183485 cites W1983661433 @default.
- W2082183485 cites W1984065278 @default.
- W2082183485 cites W1985409019 @default.
- W2082183485 cites W1987957868 @default.
- W2082183485 cites W1989998611 @default.
- W2082183485 cites W1990407294 @default.
- W2082183485 cites W1991081822 @default.
- W2082183485 cites W2000687163 @default.
- W2082183485 cites W2007413665 @default.
- W2082183485 cites W2010181165 @default.
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- W2082183485 cites W2045125226 @default.
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- W2082183485 cites W2050396941 @default.
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- W2082183485 doi "https://doi.org/10.1016/j.bmc.2012.10.039" @default.
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