FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082194532> ?p ?o ?g. }

• W2082194532 endingPage "21" @default.
• W2082194532 startingPage "2316" @default.
• W2082194532 abstract "Stimulation of a Shionogi carcinoma 115-derived cultured cell line (SC-3) with androgen resulted in secretion of heparin-binding growth factor. In this study, we analyzed cell-surfaced receptors for growth factors. Binding data of growth factors on intact SC-3 cells revealed the presence of low and high affinity receptors for epidermal growth factor (EGF), insulin, and fibroblast growth factor (FGF). The dissociation constant values were 50 pM and 1.0 nM for EGF, 1.2 nM and 30 nM for insulin, and 34 pM and 7.5 nM for FGF. The numbers of maximal binding sites were 300 and 900/cell for EGF, 2,000 and 14,000/cell for insulin, and 13,000 and 810,000/cell for FGF. To examine the association of androgen-induced growth factor with one of these receptors, the conditioned medium prepared from androgen-stimulated SC-3 cells was fractionated through a heparin-Sepharose column. Growth factor activity adsorbed and eluted by 1 M NaCl from the column was comigrated with the activity inhibiting FGF-receptor association. In addition, basic 125I-FGF was cross-linked, using disuccinimidyl suberate, to the receptor with an apparent molecular weight of 130,000, whose labeling was inhibited when basic FGF, acidic FGF, or highly purified androgen-induced growth factor was present in excess. Furthermore, the highly purified growth factor-, basic FGF- or androgen-induced growth of SC-3 cells was significantly and similarly inhibited by anti-basic FGF antibody IgG. These results indicate that androgen-induced FGF-like factor acts as an autocrine growth factor via the FGF receptor in a process of SC-3 cell proliferation." @default.
• W2082194532 created "2016-06-24" @default.
• W2082194532 creator A5029683618 @default.
• W2082194532 creator A5038933208 @default.
• W2082194532 creator A5061345986 @default.
• W2082194532 creator A5073851246 @default.
• W2082194532 creator A5074129968 @default.
• W2082194532 creator A5085783938 @default.
• W2082194532 creator A5088384086 @default.
• W2082194532 date "1990-04-15" @default.
• W2082194532 modified "2023-09-23" @default.
• W2082194532 title "Interaction of androgen-induced autocrine heparin-binding growth factor with fibroblast growth factor receptor on androgen-dependent Shionogi carcinoma 115 cells." @default.
• W2082194532 cites W1498607624 @default.
• W2082194532 cites W1501542409 @default.
• W2082194532 cites W1505419196 @default.
• W2082194532 cites W1508287776 @default.
• W2082194532 cites W1568528806 @default.
• W2082194532 cites W1591495971 @default.
• W2082194532 cites W1974715669 @default.
• W2082194532 cites W1983649348 @default.
• W2082194532 cites W1998507980 @default.
• W2082194532 cites W2017724386 @default.
• W2082194532 cites W2022961230 @default.
• W2082194532 cites W2055828195 @default.
• W2082194532 cites W2089465640 @default.
• W2082194532 cites W2094504380 @default.
• W2082194532 cites W2100837269 @default.
• W2082194532 cites W2134350919 @default.
• W2082194532 cites W2163678188 @default.
• W2082194532 cites W2163955298 @default.
• W2082194532 cites W2166095082 @default.
• W2082194532 cites W2400107736 @default.
• W2082194532 cites W245747599 @default.
• W2082194532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2156616" @default.
• W2082194532 hasPublicationYear "1990" @default.
• W2082194532 type Work @default.
• W2082194532 sameAs 2082194532 @default.
• W2082194532 citedByCount "13" @default.
• W2082194532 countsByYear W20821945322015 @default.
• W2082194532 crossrefType "journal-article" @default.
• W2082194532 hasAuthorship W2082194532A5029683618 @default.
• W2082194532 hasAuthorship W2082194532A5038933208 @default.
• W2082194532 hasAuthorship W2082194532A5061345986 @default.
• W2082194532 hasAuthorship W2082194532A5073851246 @default.
• W2082194532 hasAuthorship W2082194532A5074129968 @default.
• W2082194532 hasAuthorship W2082194532A5085783938 @default.
• W2082194532 hasAuthorship W2082194532A5088384086 @default.
• W2082194532 hasConcept C121608353 @default.
• W2082194532 hasConcept C126322002 @default.
• W2082194532 hasConcept C128240485 @default.
• W2082194532 hasConcept C130287650 @default.
• W2082194532 hasConcept C134018914 @default.
• W2082194532 hasConcept C147708747 @default.
• W2082194532 hasConcept C170493617 @default.
• W2082194532 hasConcept C185592680 @default.
• W2082194532 hasConcept C2775960820 @default.
• W2082194532 hasConcept C2776362946 @default.
• W2082194532 hasConcept C2777911890 @default.
• W2082194532 hasConcept C2780192828 @default.
• W2082194532 hasConcept C61367390 @default.
• W2082194532 hasConcept C71315377 @default.
• W2082194532 hasConcept C71924100 @default.
• W2082194532 hasConcept C74373430 @default.
• W2082194532 hasConcept C86803240 @default.
• W2082194532 hasConceptScore W2082194532C121608353 @default.
• W2082194532 hasConceptScore W2082194532C126322002 @default.
• W2082194532 hasConceptScore W2082194532C128240485 @default.
• W2082194532 hasConceptScore W2082194532C130287650 @default.
• W2082194532 hasConceptScore W2082194532C134018914 @default.
• W2082194532 hasConceptScore W2082194532C147708747 @default.
• W2082194532 hasConceptScore W2082194532C170493617 @default.
• W2082194532 hasConceptScore W2082194532C185592680 @default.
• W2082194532 hasConceptScore W2082194532C2775960820 @default.
• W2082194532 hasConceptScore W2082194532C2776362946 @default.
• W2082194532 hasConceptScore W2082194532C2777911890 @default.
• W2082194532 hasConceptScore W2082194532C2780192828 @default.
• W2082194532 hasConceptScore W2082194532C61367390 @default.
• W2082194532 hasConceptScore W2082194532C71315377 @default.
• W2082194532 hasConceptScore W2082194532C71924100 @default.
• W2082194532 hasConceptScore W2082194532C74373430 @default.
• W2082194532 hasConceptScore W2082194532C86803240 @default.
• W2082194532 hasIssue "8" @default.
• W2082194532 hasLocation W20821945321 @default.
• W2082194532 hasOpenAccess W2082194532 @default.
• W2082194532 hasPrimaryLocation W20821945321 @default.
• W2082194532 hasRelatedWork W15313792 @default.
• W2082194532 hasRelatedWork W1964900679 @default.
• W2082194532 hasRelatedWork W1979274388 @default.
• W2082194532 hasRelatedWork W1987675684 @default.
• W2082194532 hasRelatedWork W2082194532 @default.
• W2082194532 hasRelatedWork W2084034452 @default.
• W2082194532 hasRelatedWork W2171605700 @default.
• W2082194532 hasRelatedWork W2288791710 @default.
• W2082194532 hasRelatedWork W2412491855 @default.
• W2082194532 hasRelatedWork W2418947476 @default.
• W2082194532 hasVolume "50" @default.
• W2082194532 isParatext "false" @default.
• W2082194532 isRetracted "false" @default.

• next