FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082199253> ?p ?o ?g. }

• W2082199253 endingPage "372" @default.
• W2082199253 startingPage "363" @default.
• W2082199253 abstract "IL-16 is a ligand and chemotactic factor for CD4+ T cells. IL-16 inhibits the CD3 mediated lymphocyte activation and proliferation. The effects of IL-16 on the target cells are dependent on the cell type, the presence of co-activators etc. To understand the regulation function and mechanism of IL-16 on target cells, we used a 130 a.a. recombinant IL-16 to study its effects on the growth of Jurkat T leukemia cells in vitro. We found that the rIL-16 stimulated the proliferation of Jurkat cells at low dose (10−9M), but inhibited the growth of the cells at higher concentration (10−5M). Results showed that 10−5 M of rIL-16 treatment induced an enhanced apoptosis in Jurkat cells. The treatment blocked the expression of FasL, but up-regulated the c-myc and Bid expression in the cells. Pre-treatment of PKC inhibitor or MEK1 inhibitor markedly increased or decreased the rIL-16 induced growth-inhibiting effects on Jurkat cells, respectively. The results suggested that the rIL-16 might be a regulator for the growth or apoptosis of Jurkat cells at a dose-dependent manner. The growth-inhibiting effects of rIL-16 might be Fas/FasL independent, but, associated with the activation of PKC, up-regulated expression of c-Myc and Bid, and the participation of the ERK signal pathway in Jurkat cells." @default.
• W2082199253 created "2016-06-24" @default.
• W2082199253 creator A5015896077 @default.
• W2082199253 creator A5085353751 @default.
• W2082199253 date "2002-12-01" @default.
• W2082199253 modified "2023-10-16" @default.
• W2082199253 title "The associated regulators and signal pathway in rIL-16/CD4 mediated growth regulation in Jurkat cells" @default.
• W2082199253 cites W1485021502 @default.
• W2082199253 cites W1498540584 @default.
• W2082199253 cites W1505173991 @default.
• W2082199253 cites W1513554303 @default.
• W2082199253 cites W1646400510 @default.
• W2082199253 cites W1965529603 @default.
• W2082199253 cites W1966700067 @default.
• W2082199253 cites W1967088529 @default.
• W2082199253 cites W1967912592 @default.
• W2082199253 cites W1974351164 @default.
• W2082199253 cites W1977499961 @default.
• W2082199253 cites W1978813721 @default.
• W2082199253 cites W1978830777 @default.
• W2082199253 cites W1990056722 @default.
• W2082199253 cites W1991476335 @default.
• W2082199253 cites W1994080507 @default.
• W2082199253 cites W1994449425 @default.
• W2082199253 cites W1997858052 @default.
• W2082199253 cites W2002733542 @default.
• W2082199253 cites W2003785741 @default.
• W2082199253 cites W2004645606 @default.
• W2082199253 cites W2014582730 @default.
• W2082199253 cites W2017185316 @default.
• W2082199253 cites W2017728303 @default.
• W2082199253 cites W2023899068 @default.
• W2082199253 cites W2028249636 @default.
• W2082199253 cites W2058384478 @default.
• W2082199253 cites W2071607357 @default.
• W2082199253 cites W2078704491 @default.
• W2082199253 cites W2086313080 @default.
• W2082199253 cites W2086766576 @default.
• W2082199253 cites W2087472697 @default.
• W2082199253 cites W2099787406 @default.
• W2082199253 cites W2105428498 @default.
• W2082199253 cites W2117346996 @default.
• W2082199253 cites W2140516956 @default.
• W2082199253 cites W2152305777 @default.
• W2082199253 cites W2160706286 @default.
• W2082199253 cites W2168338776 @default.
• W2082199253 cites W2169268397 @default.
• W2082199253 cites W2170449608 @default.
• W2082199253 doi "https://doi.org/10.1038/sj.cr.7290138" @default.
• W2082199253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12528894" @default.
• W2082199253 hasPublicationYear "2002" @default.
• W2082199253 type Work @default.
• W2082199253 sameAs 2082199253 @default.
• W2082199253 citedByCount "11" @default.
• W2082199253 countsByYear W20821992532013 @default.
• W2082199253 countsByYear W20821992532016 @default.
• W2082199253 countsByYear W20821992532021 @default.
• W2082199253 countsByYear W20821992532022 @default.
• W2082199253 crossrefType "journal-article" @default.
• W2082199253 hasAuthorship W2082199253A5015896077 @default.
• W2082199253 hasAuthorship W2082199253A5085353751 @default.
• W2082199253 hasBestOaLocation W20821992531 @default.
• W2082199253 hasConcept C104317684 @default.
• W2082199253 hasConcept C153911025 @default.
• W2082199253 hasConcept C179464577 @default.
• W2082199253 hasConcept C190283241 @default.
• W2082199253 hasConcept C203014093 @default.
• W2082199253 hasConcept C2776090121 @default.
• W2082199253 hasConcept C31573885 @default.
• W2082199253 hasConcept C55493867 @default.
• W2082199253 hasConcept C57074206 @default.
• W2082199253 hasConcept C62112901 @default.
• W2082199253 hasConcept C62478195 @default.
• W2082199253 hasConcept C66008609 @default.
• W2082199253 hasConcept C6929976 @default.
• W2082199253 hasConcept C86803240 @default.
• W2082199253 hasConcept C8891405 @default.
• W2082199253 hasConcept C95444343 @default.
• W2082199253 hasConceptScore W2082199253C104317684 @default.
• W2082199253 hasConceptScore W2082199253C153911025 @default.
• W2082199253 hasConceptScore W2082199253C179464577 @default.
• W2082199253 hasConceptScore W2082199253C190283241 @default.
• W2082199253 hasConceptScore W2082199253C203014093 @default.
• W2082199253 hasConceptScore W2082199253C2776090121 @default.
• W2082199253 hasConceptScore W2082199253C31573885 @default.
• W2082199253 hasConceptScore W2082199253C55493867 @default.
• W2082199253 hasConceptScore W2082199253C57074206 @default.
• W2082199253 hasConceptScore W2082199253C62112901 @default.
• W2082199253 hasConceptScore W2082199253C62478195 @default.
• W2082199253 hasConceptScore W2082199253C66008609 @default.
• W2082199253 hasConceptScore W2082199253C6929976 @default.
• W2082199253 hasConceptScore W2082199253C86803240 @default.
• W2082199253 hasConceptScore W2082199253C8891405 @default.
• W2082199253 hasConceptScore W2082199253C95444343 @default.
• W2082199253 hasIssue "5-6" @default.
• W2082199253 hasLocation W20821992531 @default.
• W2082199253 hasLocation W20821992532 @default.
• W2082199253 hasOpenAccess W2082199253 @default.

• next