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- W2082202100 endingPage "14751" @default.
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- W2082202100 abstract "Painful experiences are multilayered, composed of sensory, affective, cognitive and behavioral facets. Whereas it is well accepted that the development of chronic pain is due to maladaptive neuronal changes, the underlying molecular mechanisms, their relationship to the different pain modalities, and indeed the localization of these changes are still unknown. Brain-derived neurotrophic factor (BDNF) is an activity-dependent neuromodulator in the adult brain, which enhances neuronal excitability. In the spinal cord, BDNF underlies the development and maintenance of inflammatory and neuropathic pain. Here, we hypothesized that BDNF could be a trigger of some of these plastic changes. Our results demonstrate that BDNF is upregulated in the anterior cingulate cortex (ACC) and the primary sensory cortex (S1) in rats with inflammatory pain. Injections of recombinant BDNF (into the ACC) or a viral vector synthesizing BDNF (into the ACC or S1) triggered both neuronal hyperexcitability, as shown by elevated long-term potentiation, and sustained pain hypersensitivity. Finally, pharmacological blockade of BDNF-tropomyosin receptor kinase B (TrkB) signaling in the ACC, through local injection of cyclotraxin-B (a novel, highly potent, and selective TrkB antagonist) prevented neuronal hyperexcitability, the emergence of cold hypersensitivity, and passive avoidance behavior. These findings show that BDNF-dependent neuronal plasticity in the ACC, a structure known to be involved in the affective-emotional aspect of pain, is a key mechanism in the development and maintenance of the emotional aspect of chronic pain." @default.
- W2082202100 created "2016-06-24" @default.
- W2082202100 creator A5003780805 @default.
- W2082202100 creator A5011097362 @default.
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- W2082202100 creator A5049623064 @default.
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- W2082202100 creator A5059823264 @default.
- W2082202100 creator A5084817390 @default.
- W2082202100 creator A5088306151 @default.
- W2082202100 date "2014-10-29" @default.
- W2082202100 modified "2023-10-17" @default.
- W2082202100 title "BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain" @default.
- W2082202100 cites W117431324 @default.
- W2082202100 cites W1484813864 @default.
- W2082202100 cites W150383275 @default.
- W2082202100 cites W1558012505 @default.
- W2082202100 cites W1565438915 @default.
- W2082202100 cites W1625740378 @default.
- W2082202100 cites W1671390315 @default.
- W2082202100 cites W1905800278 @default.
- W2082202100 cites W1918871866 @default.
- W2082202100 cites W1966351672 @default.
- W2082202100 cites W1967217032 @default.
- W2082202100 cites W1969208467 @default.
- W2082202100 cites W1970491043 @default.
- W2082202100 cites W1974476511 @default.
- W2082202100 cites W1974602251 @default.
- W2082202100 cites W1977999433 @default.
- W2082202100 cites W1978269241 @default.
- W2082202100 cites W1979845035 @default.
- W2082202100 cites W1982326881 @default.
- W2082202100 cites W1983257841 @default.
- W2082202100 cites W1984084387 @default.
- W2082202100 cites W1984929819 @default.
- W2082202100 cites W1985637161 @default.
- W2082202100 cites W1986449227 @default.
- W2082202100 cites W1987108500 @default.
- W2082202100 cites W1992832141 @default.
- W2082202100 cites W1993267237 @default.
- W2082202100 cites W1994669081 @default.
- W2082202100 cites W1995458911 @default.
- W2082202100 cites W1995796629 @default.
- W2082202100 cites W1997151932 @default.
- W2082202100 cites W2000079550 @default.
- W2082202100 cites W2001615001 @default.
- W2082202100 cites W2004738269 @default.
- W2082202100 cites W2010447756 @default.
- W2082202100 cites W2011965698 @default.
- W2082202100 cites W2013718038 @default.
- W2082202100 cites W2014337228 @default.
- W2082202100 cites W2018854937 @default.
- W2082202100 cites W2023718219 @default.
- W2082202100 cites W2024014699 @default.
- W2082202100 cites W2025577666 @default.
- W2082202100 cites W2025978099 @default.
- W2082202100 cites W2028126031 @default.
- W2082202100 cites W2029863311 @default.
- W2082202100 cites W2031343751 @default.
- W2082202100 cites W2037919084 @default.
- W2082202100 cites W2038765440 @default.
- W2082202100 cites W2043946280 @default.
- W2082202100 cites W2048908758 @default.
- W2082202100 cites W2051900716 @default.
- W2082202100 cites W2052481577 @default.
- W2082202100 cites W2055019464 @default.
- W2082202100 cites W2055541457 @default.
- W2082202100 cites W2059839512 @default.
- W2082202100 cites W2065110456 @default.
- W2082202100 cites W2065371327 @default.
- W2082202100 cites W2069535476 @default.
- W2082202100 cites W2071127132 @default.
- W2082202100 cites W2071358232 @default.
- W2082202100 cites W2073825915 @default.
- W2082202100 cites W2077714559 @default.
- W2082202100 cites W2078316783 @default.
- W2082202100 cites W2083113102 @default.
- W2082202100 cites W2083833206 @default.
- W2082202100 cites W2084518320 @default.
- W2082202100 cites W2085955270 @default.
- W2082202100 cites W2089458218 @default.
- W2082202100 cites W2094992069 @default.
- W2082202100 cites W2103393785 @default.
- W2082202100 cites W2114950967 @default.
- W2082202100 cites W2120566849 @default.
- W2082202100 cites W2125197016 @default.
- W2082202100 cites W2128692107 @default.
- W2082202100 cites W2128994172 @default.
- W2082202100 cites W2130494624 @default.
- W2082202100 cites W2131110619 @default.
- W2082202100 cites W2131165483 @default.
- W2082202100 cites W2137979524 @default.
- W2082202100 cites W2148423001 @default.
- W2082202100 cites W2150321495 @default.
- W2082202100 cites W2159980203 @default.
- W2082202100 cites W2170380292 @default.