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- W2082202978 abstract "Purpose To identify and validate serum biomarkers for the progression of D uchenne muscular dystrophy ( DMD ) using a MS ‐based bottom‐up pipeline. Experimental design We used a bottom‐up proteomics approach, including a protein concentration equalization step, different proteolytic digestions, and MS detection schemes, to identify candidate biomarkers in serum samples from control subjects and DMD patients. Fibronectin was chosen for follow‐up based on the differences in peptide spectral counts and sequence coverage observed between the DMD and control groups. Subsequently, fibronectin levels were determined with ELISA in 68 DMD patients, 38 milder B ecker muscular dystrophy patients, 33 patients with other neuromuscular disorders, and 15 age‐matched adult and child controls. Results There was a significant increase in fibronectin levels in DMD patients compared to age‐matched controls. Fibronectin levels in patients with B ecker muscular dystrophy, B ethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years. Conclusion and clinical relevance This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients." @default.
- W2082202978 created "2016-06-24" @default.
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- W2082202978 date "2014-03-11" @default.
- W2082202978 modified "2023-10-16" @default.
- W2082202978 title "Fibronectin is a serum biomarker for <scp>D</scp> uchenne muscular dystrophy" @default.
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- W2082202978 doi "https://doi.org/10.1002/prca.201300072" @default.
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