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- W2082207877 abstract "We thank Kountouras and colleagues, Lie and Xie, and Lo for their valuable comments in response to our Review. Guillain-Barré syndromeWe read with interest the Review by van Doorn and co-workers.1 These authors state that Campylobacter jejuni is the most commonly identified infection that precedes Guillain-Barré syndrome (GBS), and they discuss evidence that this infection contributes to the pathogenesis of GBS through molecular mimicry and a cross-reactive immune response. However, the authors did not mention Helicobacter pylori infection, a crucial antecedent infection that, like C jejuni, seems to be associated with the development of autoimmune sequelae observed in peripheral neuropathies and GBS. Full-Text PDF Guillain-Barré syndromeWe agree with van Doorn and co-workers that more trials are needed to study the effectiveness of treatments for Guillain-Barré syndrome (GBS) on the basis of GBS outcome prognostic scores because “the course of GBS in individual patients is highly variable and the effect of treatment can be shown only by comparing groups of patients”.1 We advocate the use of more comprehensive outcome measures and earlier randomisation of patients in trials. Full-Text PDF Guillain-Barré syndromeGuillain-Barré syndrome (GBS), including the Miller Fisher syndrome (MFS) subtype of GBS, and Bickerstaff's brainstem encephalitis (BBE) are immune-mediated disorders that have overlapping clinical features. Anti-GQ1b antibody is widely regarded to play a critical part in the pathogenesis of these disorders;1 this antibody is detected in 26% of cases of GBS, 66% of cases of BBE, and in up to 95% of cases of MFS.2 van Doorn and co-workers3 have comprehensively reviewed the clinical features, pathogenesis, and treatment of GBS, reminding us that, despite its self-limiting nature, there is still considerable mortality and morbidity from this disorder. Full-Text PDF" @default.
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- W2082207877 date "2008-12-01" @default.
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- W2082207877 title "Guillain-Barré syndrome – Authors' reply" @default.
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- W2082207877 doi "https://doi.org/10.1016/s1474-4422(08)70250-3" @default.
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