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• W2082221919 endingPage "316" @default.
• W2082221919 startingPage "309" @default.
• W2082221919 abstract "Abstract: Arachidonic acid, a major polyunsaturated fatty acid of membrane phospholipids in the CNS, reduced the high-affinity uptake of glutamate and γ-aminobutyric acid (GABA) in both rat brain cortical slices and synaptosomes. α-Aminoisobutyric acid uptake was not affected. Intrasynaptosomal sodium was increased concomitant with decreased (Na++ K+)-ATPase activity in synaptosomal membranes. The reduction of GABA uptake in synaptosomes could be partially reversed by α-tocopherol. The inhibition of membrane-bound (Na++K+)-ATPase by arachidonic acid was not due to a simple detergent-like action on membranes, since sodium dodecyl sulfate stimulated the sodium pump activity in synaptosomes. These data indicate that arachidonic acid selectively modifies membrane stability and integrity associated with reductions of GABA and glutamate uptake and of (Na++ K+)-ATPase activity." @default.
• W2082221919 created "2016-06-24" @default.
• W2082221919 creator A5026283153 @default.
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• W2082221919 date "1983-02-01" @default.
• W2082221919 modified "2023-09-27" @default.
• W2082221919 title "Reductions of ?-Aminobutyric Acid and Glutamate Uptake and (Na⁺+ K⁺)-ATPase Activity in Brain Slices and Synaptosomes by Arachidonic Acid" @default.
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• W2082221919 doi "https://doi.org/10.1111/j.1471-4159.1983.tb11284.x" @default.
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