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- W2082237481 abstract "Neuroblastoma (NBL) in children usually occurs in a sporadic form. However, it rarely occurs in families. Recently, the familial neuroblastoma (FNB) locus has been mapped to 16p12-p13 by linkage analysis.Here we show the result of loss of heterozygosity in the region spanning 16p12-p13 (D16S406-D16S409, 46 cM) in 470 NBLs including both sporadic and mass screening cases.Allelic loss was found in 61(13%) tumors. Deletion of 16p was associated with mass screening tumor (P = 0.035) and <1 year of age at diagnosis (P = 0.048). We found two commonly deleted regions: the sizes of the region were approximately 2 cM and approximately 6 cM.Our data suggested that allelic loss of 16p was common in favorable NBLs, and there may be at least two candidate loci within the region of FNB." @default.
- W2082237481 created "2016-06-24" @default.
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- W2082237481 date "2000-01-01" @default.
- W2082237481 modified "2023-10-17" @default.
- W2082237481 title "Analysis of loss of heterozygosity at 16p12-p13 (familial neuroblastoma locus) in 470 neuroblastomas including both sporadic and mass screening tumors" @default.
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- W2082237481 doi "https://doi.org/10.1002/1096-911x(20001201)35:6<531::aid-mpo6>3.0.co;2-2" @default.
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