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- W2082240719 abstract "The purpose of the present study was to investigate, at the myocardial level, teh divergent influences of Ca2+ on the action of various cardiotonic steroids. Therefore, the cardiac uptake of 3H-digitoxin and 3H-digoxin was studied in experiments on guinea pig isolated hearts. The following results were obtained: with digitoxin the increase of the extracellular calcium concentration from 0.45 upto 7.2 mM resulted in a concomitant decrease of the myocardial glycoside uptake from about 1.8 nmoles/g wet weight down to about 1.2 nmoles/g wet weight. Similar results were obtained when digoxin uptake was studied under the same conditions: with 0.45 mM Ca2+ about 0.6 nmoles/g wet weight were bound, increasing the calcium concentration upto 7.2 mM lead to a concomitant decrease of the cardiac digoxin uptake down to about 0.45 nmoles/g wet weight. Despite the different physiochemical behaviour of these two drugs and the different amounts of drug present in the hearts the influence of Ca2+ was almost identical if calculated on a relative basis. So far, no experimental based explanation can be given for the above discrepancies. Other possible interpretation discussed." @default.
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- W2082240719 date "1975-02-01" @default.
- W2082240719 modified "2023-09-25" @default.
- W2082240719 title "Dependence of the cardiac uptake of digitalis glucosides on the extracellular calcium concentration in guinea pig isolated hearts" @default.
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- W2082240719 doi "https://doi.org/10.1016/0014-2999(75)90098-9" @default.
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