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• W2082265331 abstract "The possible degradation of the tumor antigen epitope gp100(280-288) (YLEPGPVTA) in the presence of the monocyte-like line U937, and the effect of degradation on the in vitro-measured immune recognition, were investigated by chromatographic techniques and immunological assays. Results indicate a rapid hydrolysis of the substrate in the presence of the model cells, which is consistent with the hypothesis that degradation of gp100(280-288) is caused by the activity of U937-expressed enzymes, specifically amino- and carboxypeptidases. On the other hand, these results do not support the involvement of other enzymes known to be expressed by U937 cells. From a functional point of view, these data indicate that the degradation of gp100(280-288) severely hampered recognition by specific CTL clones. The results obtained may provide a model for epitope degradation by the antigen-presenting cells found in defined anatomical compartments and may, at least in part, account for the low activity of peptide-based antineoplastic vaccines, as well as for the transience of the effects of subcutaneously administered peptides in general." @default.
• W2082265331 created "2016-06-24" @default.
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• W2082265331 date "2003-03-01" @default.
• W2082265331 modified "2023-09-28" @default.
• W2082265331 title "Degradation of the immunogenic peptide gp100280–288 by the monocyte-like U937 cell line" @default.
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• W2082265331 doi "https://doi.org/10.1016/s0196-9781(03)00051-2" @default.
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