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- W2082273296 abstract "• The in vivo antibacterial effectiveness in the rabbit cornea of several commercially available ophthalmic antibiotic preparations was determined against a single strain of<i>Pseudomonas aeruginosa</i>isolated from a human corneal ulcer. Each antibiotic was instilled topically at hourly intervals, and the number of residual viable organisms in the cornea subsequently was ascertained. In vivo measurements correlated well with in vitro data and with generally held clinical impressions. Three antibiotics, gentamicin sulfate, polymyxin B sulfate, and colistin sulfate, suppressed corneal growth of<i>P aeruginosa</i>in commercially available concentrations. Gentamicin was slightly more effective than polymyxin B; both drugs were substantially more effective than colistin. Formulations of gentamicin and polymyxin B containing approximately four times the quantity of drug found in commercial preparations eliminated this<i>P aeruginosa</i>strain from the cornea much more rapidly than did the commercial preparations." @default.
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- W2082273296 date "1979-09-01" @default.
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- W2082273296 title "Topical Antibiotic Therapy of Pseudomonas aeruginosa Keratitis" @default.
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- W2082273296 doi "https://doi.org/10.1001/archopht.1979.01020020267016" @default.
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