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• W2082273886 abstract "Background : Patients with Bell’s Palsy (BP): a very common neuropathy of the facial nerve-showed significant decreases of T- and B-lymphocytes in earlier studies. Besides a viral infection an autoimmune process leading to this disease has been discussed. Methods : 15 patients with BP and 15 healthy, age-matched individuals were included in this study. In addition to routine blood parameters peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll density gradient. Afterwards, in CD14 + (monocytes), CD68 + (macrophages), CD3 + (T-lymphocytes) or CD19 + (B-lymphocytes) the percentage of cells, expressing pro-inflammatory (CD40, TNF- α , and COX-2), pro-apoptotic (Caspase-3, PARP), pro-adhesive (CD38) and oxidative stress-related (MnSOD) proteins were measured by two-color fluorescence-activated cell sorter analyses.  Results: In comparison to healthy individuals, patients with BP revealed significantly elevated plasma levels of C-reactive protein and total leukocyte count, while levels of T- and B-lymphocytes were significantly decreased. In BP patients all subpopulations under test showed a significant increase in percentage of CD38 + as well as of pro-inflammatory (CD40 + , TNF- α + ) cells; additionally monocytes showed a significant increase in percentage of MnSOD positive cells.  Conclusions: Our data shows new evidence for an involvement of the immune system in BP. Therefore, we suggest that future investigations of PBMCs in BP patients represent a very promising approach to further elucidate possible pathomechanisms. doi:10.4021/ jnr108 w" @default.
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• W2082273886 date "2012-07-05" @default.
• W2082273886 modified "2023-09-26" @default.
• W2082273886 title "Changes in Peripheral Blood Mononuclear Cells - Novel Evidence for an Immunomodulatory Aspect in Bell’s Palsy?" @default.
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• W2082273886 doi "https://doi.org/10.4021/jnr.v2i3.108" @default.
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