Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082299506> ?p ?o ?g. }
- W2082299506 endingPage "15035" @default.
- W2082299506 startingPage "15027" @default.
- W2082299506 abstract "Metaplasticity, the adaptive changes of long-term potentiation (LTP) and long-term depression (LTD) in response to fluctuations in neural activity is well documented in visual cortex, where dark rearing shifts the frequency threshold for the induction of LTP and LTD. Here we studied metaplasticity affecting spike-timing-dependent plasticity, in which the polarity of plasticity is determined not by the stimulation frequency, but by the temporal relationship between near-coincidental presynaptic and postsynaptic firing. We found that in mouse visual cortex the same regime of deprivation that restricts the frequency range for inducing rate-dependent LTD extends the integration window for inducing timing-dependent LTD, enabling LTD induction with random presynaptic and postsynaptic firing. Notably, the underlying mechanism for the changes in both rate-dependent and time-dependent LTD appears to be an increase of NR2b-containing NMDAR at the synapse. Thus, the rules of metaplasticity might manifest in opposite directions, depending on the plasticity-induction paradigms." @default.
- W2082299506 created "2016-06-24" @default.
- W2082299506 creator A5017943286 @default.
- W2082299506 creator A5028998723 @default.
- W2082299506 creator A5055376447 @default.
- W2082299506 creator A5064663421 @default.
- W2082299506 creator A5081037450 @default.
- W2082299506 creator A5081083183 @default.
- W2082299506 creator A5084534209 @default.
- W2082299506 date "2012-10-24" @default.
- W2082299506 modified "2023-10-07" @default.
- W2082299506 title "Dark Exposure Extends the Integration Window for Spike-Timing-Dependent Plasticity" @default.
- W2082299506 cites W1502426712 @default.
- W2082299506 cites W1733248925 @default.
- W2082299506 cites W1975402449 @default.
- W2082299506 cites W1985322212 @default.
- W2082299506 cites W1990501032 @default.
- W2082299506 cites W1993004513 @default.
- W2082299506 cites W2008744372 @default.
- W2082299506 cites W2009365661 @default.
- W2082299506 cites W2011331399 @default.
- W2082299506 cites W2015144766 @default.
- W2082299506 cites W2019027754 @default.
- W2082299506 cites W2021144046 @default.
- W2082299506 cites W2038091915 @default.
- W2082299506 cites W2038365936 @default.
- W2082299506 cites W2046104691 @default.
- W2082299506 cites W2047912472 @default.
- W2082299506 cites W2049443838 @default.
- W2082299506 cites W2050066016 @default.
- W2082299506 cites W2060647065 @default.
- W2082299506 cites W2065015746 @default.
- W2082299506 cites W2067415178 @default.
- W2082299506 cites W2079048646 @default.
- W2082299506 cites W2079147025 @default.
- W2082299506 cites W2089413793 @default.
- W2082299506 cites W2089736335 @default.
- W2082299506 cites W2092669952 @default.
- W2082299506 cites W2094813482 @default.
- W2082299506 cites W2103594871 @default.
- W2082299506 cites W2107433900 @default.
- W2082299506 cites W2110240734 @default.
- W2082299506 cites W2115168491 @default.
- W2082299506 cites W2117531252 @default.
- W2082299506 cites W2125438547 @default.
- W2082299506 cites W2128125306 @default.
- W2082299506 cites W2131369634 @default.
- W2082299506 cites W2138931746 @default.
- W2082299506 cites W2138940294 @default.
- W2082299506 cites W2141911467 @default.
- W2082299506 cites W2145242428 @default.
- W2082299506 cites W2146521940 @default.
- W2082299506 cites W2146732533 @default.
- W2082299506 cites W2152696633 @default.
- W2082299506 cites W2154045630 @default.
- W2082299506 cites W2159014212 @default.
- W2082299506 cites W2431455885 @default.
- W2082299506 cites W4241275657 @default.
- W2082299506 doi "https://doi.org/10.1523/jneurosci.2545-12.2012" @default.
- W2082299506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3496177" @default.
- W2082299506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23100424" @default.
- W2082299506 hasPublicationYear "2012" @default.
- W2082299506 type Work @default.
- W2082299506 sameAs 2082299506 @default.
- W2082299506 citedByCount "48" @default.
- W2082299506 countsByYear W20822995062013 @default.
- W2082299506 countsByYear W20822995062014 @default.
- W2082299506 countsByYear W20822995062015 @default.
- W2082299506 countsByYear W20822995062016 @default.
- W2082299506 countsByYear W20822995062017 @default.
- W2082299506 countsByYear W20822995062018 @default.
- W2082299506 countsByYear W20822995062019 @default.
- W2082299506 countsByYear W20822995062021 @default.
- W2082299506 countsByYear W20822995062022 @default.
- W2082299506 countsByYear W20822995062023 @default.
- W2082299506 crossrefType "journal-article" @default.
- W2082299506 hasAuthorship W2082299506A5017943286 @default.
- W2082299506 hasAuthorship W2082299506A5028998723 @default.
- W2082299506 hasAuthorship W2082299506A5055376447 @default.
- W2082299506 hasAuthorship W2082299506A5064663421 @default.
- W2082299506 hasAuthorship W2082299506A5081037450 @default.
- W2082299506 hasAuthorship W2082299506A5081083183 @default.
- W2082299506 hasAuthorship W2082299506A5084534209 @default.
- W2082299506 hasBestOaLocation W20822995061 @default.
- W2082299506 hasConcept C112592302 @default.
- W2082299506 hasConcept C121332964 @default.
- W2082299506 hasConcept C127445978 @default.
- W2082299506 hasConcept C15744967 @default.
- W2082299506 hasConcept C159919123 @default.
- W2082299506 hasConcept C160268369 @default.
- W2082299506 hasConcept C169760540 @default.
- W2082299506 hasConcept C170493617 @default.
- W2082299506 hasConcept C17077164 @default.
- W2082299506 hasConcept C194973443 @default.
- W2082299506 hasConcept C197341189 @default.
- W2082299506 hasConcept C24998067 @default.
- W2082299506 hasConcept C25274449 @default.
- W2082299506 hasConcept C26410512 @default.