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- W2082303947 abstract "Cyclosporin A inhibited at equal concentrations both the proliferative response and the generation of cytotoxic T lymphocytes in one-way mouse spleen cell mixed lymphocyte culture. The 50% inhibitory concentration was in all experiments 10(-2) to 10(-1) microgram/ml. The inhibition was directly proportional to how early the drug was added to the culture: a complete inhibition of both responses was obtained if the drug was added on day 3, and a partial inhibition if added on day 4 of culture. Cytological analysis of the cultured cells demonstrated that resting lymphocytes were not damaged at 100-1000-fold concentrations of the drug giving complete inhibition of the blastogenic response. The results suggest that cyclosporin A is most effective if present throughout the induction phase of the immune response." @default.
- W2082303947 created "2016-06-24" @default.
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- W2082303947 date "1980-12-01" @default.
- W2082303947 modified "2023-09-23" @default.
- W2082303947 title "Effect of Cyclosporin A on the Generation of Cytotoxic T Lymphocytes in Mouse Mixed Lymphocyte Culture" @default.
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- W2082303947 doi "https://doi.org/10.1111/j.1365-3083.1980.tb00096.x" @default.
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