Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082304405> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2082304405 endingPage "A27" @default.
- W2082304405 startingPage "A27" @default.
- W2082304405 abstract "The present study was designed to explore the possible changes in endogenous hydrogen sulphide (H2S), a novel gasotransmitter, on the pathogenesis of allergic rhinitis (AR).AR guinea pig model was established by nasal ovalbumin sensitisation. Guinea pigs were divided into four groups: Saline control, AR sensitised, sodium hydrosulphide (NaHS) treated, and propargylglycine (PPG) treated group. The frequency of sneezing and nose rubbing was recorded. Leukocyte infiltration in nasal lavage fluid (NLF) and plasma H2S level were measured. Expression of Cystathionine-β-synthase (CBS) and Cystathionine-γ-lyase (CSE) mRNA as H2S-producing enzymes in nasal mucosa was determined by real time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR).The frequency of sneezing and nose rubbing, and levels of leukocyte infiltration in NLF were higher than those of control (P<0.01), but plasma H2S in sensitised guinea pigs was lower than those of control (P<0.05). From the results of RT-PCR, it was found that the expression of CSE was higher than CBS in nasal mucosa, and in sensitised guinea pigs it was lower than that of control (P<0.05). NaHS successfully increased the level of H2S and alleviated the symptoms of AR accompanied by up-regulation of CSE as compared with AR group (P<0.05). PPG significantly suppressed the expression of CSE and decreased the H2S level, yet also aggravated the symptoms of AR.H2S level may be negatively correlated with the process of inflammation and positively correlated with expression of CSE in nasal mucosa. The endogenous H2S pathway is down-regulated in AR." @default.
- W2082304405 created "2016-06-24" @default.
- W2082304405 creator A5015785232 @default.
- W2082304405 creator A5026227741 @default.
- W2082304405 creator A5037670442 @default.
- W2082304405 date "2013-09-01" @default.
- W2082304405 modified "2023-09-27" @default.
- W2082304405 title "Oxidative stress induces smooth muscle dedifferentiation in placental stem villus arteries through reduced hydrogen sulphide production by cystathionine-γ-lyase" @default.
- W2082304405 doi "https://doi.org/10.1016/j.placenta.2013.06.081" @default.
- W2082304405 hasPublicationYear "2013" @default.
- W2082304405 type Work @default.
- W2082304405 sameAs 2082304405 @default.
- W2082304405 citedByCount "0" @default.
- W2082304405 crossrefType "journal-article" @default.
- W2082304405 hasAuthorship W2082304405A5015785232 @default.
- W2082304405 hasAuthorship W2082304405A5026227741 @default.
- W2082304405 hasAuthorship W2082304405A5037670442 @default.
- W2082304405 hasConcept C126322002 @default.
- W2082304405 hasConcept C134018914 @default.
- W2082304405 hasConcept C16525657 @default.
- W2082304405 hasConcept C16685009 @default.
- W2082304405 hasConcept C181199279 @default.
- W2082304405 hasConcept C185592680 @default.
- W2082304405 hasConcept C187566844 @default.
- W2082304405 hasConcept C203014093 @default.
- W2082304405 hasConcept C2776151105 @default.
- W2082304405 hasConcept C2776946954 @default.
- W2082304405 hasConcept C2779201268 @default.
- W2082304405 hasConcept C2780942790 @default.
- W2082304405 hasConcept C55493867 @default.
- W2082304405 hasConcept C59377437 @default.
- W2082304405 hasConcept C71924100 @default.
- W2082304405 hasConcept C8891405 @default.
- W2082304405 hasConceptScore W2082304405C126322002 @default.
- W2082304405 hasConceptScore W2082304405C134018914 @default.
- W2082304405 hasConceptScore W2082304405C16525657 @default.
- W2082304405 hasConceptScore W2082304405C16685009 @default.
- W2082304405 hasConceptScore W2082304405C181199279 @default.
- W2082304405 hasConceptScore W2082304405C185592680 @default.
- W2082304405 hasConceptScore W2082304405C187566844 @default.
- W2082304405 hasConceptScore W2082304405C203014093 @default.
- W2082304405 hasConceptScore W2082304405C2776151105 @default.
- W2082304405 hasConceptScore W2082304405C2776946954 @default.
- W2082304405 hasConceptScore W2082304405C2779201268 @default.
- W2082304405 hasConceptScore W2082304405C2780942790 @default.
- W2082304405 hasConceptScore W2082304405C55493867 @default.
- W2082304405 hasConceptScore W2082304405C59377437 @default.
- W2082304405 hasConceptScore W2082304405C71924100 @default.
- W2082304405 hasConceptScore W2082304405C8891405 @default.
- W2082304405 hasIssue "9" @default.
- W2082304405 hasLocation W20823044051 @default.
- W2082304405 hasOpenAccess W2082304405 @default.
- W2082304405 hasPrimaryLocation W20823044051 @default.
- W2082304405 hasRelatedWork W1978559596 @default.
- W2082304405 hasRelatedWork W2091008837 @default.
- W2082304405 hasRelatedWork W2141513317 @default.
- W2082304405 hasRelatedWork W2303649760 @default.
- W2082304405 hasRelatedWork W2467101046 @default.
- W2082304405 hasRelatedWork W2719909325 @default.
- W2082304405 hasRelatedWork W2748952813 @default.
- W2082304405 hasRelatedWork W2883728153 @default.
- W2082304405 hasRelatedWork W3138331279 @default.
- W2082304405 hasRelatedWork W4225120151 @default.
- W2082304405 hasVolume "34" @default.
- W2082304405 isParatext "false" @default.
- W2082304405 isRetracted "false" @default.
- W2082304405 magId "2082304405" @default.
- W2082304405 workType "article" @default.