FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082316703> ?p ?o ?g. }

• W2082316703 endingPage "159" @default.
• W2082316703 startingPage "151" @default.
• W2082316703 abstract "Despite the fidelity of host cell polymerases, the human papillomavirus (HPV) displays a degree of genomic polymorphism resulting in distinct genotypes and intra-type variants. The current HPV vaccines target the most prevalent genotypes associated with cervical cancer (HPV16/18) and genital warts (HPV6/11). Although these vaccines confer some measure of cross-protection, a multivalent HPV vaccine is in the pipeline that aims to broaden vaccine protection against other cervical cancer-associated genotypes including HPV31, HPV33, HPV45, HPV52 and HPV58. Both current and next generation vaccines comprise virus-like particles, based upon the major capsid protein, L1, and vaccine-induced, type-specific protection is likely mediated by neutralizing antibodies targeting L1 surface-exposed domains. The aim of this study was to perform an in silico analysis of existing full length L1 sequences representing vaccine-relevant HPV genotypes in order to address the degree of naturally-occurring, intra-type polymorphisms. In total, 1281 sequences from the Americas, Africa, Asia and Europe were assembled. Intra-type entropy was low and/or limited to non-surface-exposed residues for HPV6, HPV11 and HPV52 suggesting a minimal effect on vaccine antibodies for these genotypes. For HPV16, intra-type entropy was high but the present analysis did not reveal any significant polymorphisms not previously identified. For HPV31, HPV33, HPV58, however, intra-type entropy was high, mostly mapped to surface-exposed domains and in some cases within known neutralizing antibody epitopes. For HPV18 and HPV45 there were too few sequences for a definitive analysis, but HPV45 displayed some degree of surface-exposed residue diversity. In most cases, the reference sequence for each genotype represented a minority variant and the consensus L1 sequences for HPV18, HPV31, HPV45 and HPV58 did not reflect the L1 sequence of the currently available HPV pseudoviruses. These data highlight a number of variant amino acid residues that warrant further investigation for vaccine and natural history studies of HPV." @default.
• W2082316703 created "2016-06-24" @default.
• W2082316703 creator A5024940167 @default.
• W2082316703 creator A5033794499 @default.
• W2082316703 creator A5050053792 @default.
• W2082316703 date "2013-08-01" @default.
• W2082316703 modified "2023-09-26" @default.
• W2082316703 title "Amino acid sequence diversity of the major human papillomavirus capsid protein: Implications for current and next generation vaccines" @default.
• W2082316703 cites W1489188497 @default.
• W2082316703 cites W1776540003 @default.
• W2082316703 cites W1821241641 @default.
• W2082316703 cites W1915828783 @default.
• W2082316703 cites W1963888311 @default.
• W2082316703 cites W1964927845 @default.
• W2082316703 cites W1967089642 @default.
• W2082316703 cites W1967254492 @default.
• W2082316703 cites W1971854603 @default.
• W2082316703 cites W1972036595 @default.
• W2082316703 cites W1973749450 @default.
• W2082316703 cites W1979230907 @default.
• W2082316703 cites W1983330985 @default.
• W2082316703 cites W1990068438 @default.
• W2082316703 cites W1996266688 @default.
• W2082316703 cites W2001429203 @default.
• W2082316703 cites W2005304154 @default.
• W2082316703 cites W2005791824 @default.
• W2082316703 cites W2009914637 @default.
• W2082316703 cites W2015642465 @default.
• W2082316703 cites W2015905519 @default.
• W2082316703 cites W2021614645 @default.
• W2082316703 cites W2026322085 @default.
• W2082316703 cites W2027418145 @default.
• W2082316703 cites W2035185947 @default.
• W2082316703 cites W2036475509 @default.
• W2082316703 cites W2037158859 @default.
• W2082316703 cites W2037903945 @default.
• W2082316703 cites W2044523934 @default.
• W2082316703 cites W2048390601 @default.
• W2082316703 cites W2086404290 @default.
• W2082316703 cites W2105554064 @default.
• W2082316703 cites W2112859230 @default.
• W2082316703 cites W2114391710 @default.
• W2082316703 cites W2117995803 @default.
• W2082316703 cites W2119264365 @default.
• W2082316703 cites W2124248268 @default.
• W2082316703 cites W2125121305 @default.
• W2082316703 cites W2125727207 @default.
• W2082316703 cites W2132831528 @default.
• W2082316703 cites W2135045906 @default.
• W2082316703 cites W2136797609 @default.
• W2082316703 cites W2137152767 @default.
• W2082316703 cites W2139908711 @default.
• W2082316703 cites W2140333504 @default.
• W2082316703 cites W2143759583 @default.
• W2082316703 cites W2148969651 @default.
• W2082316703 cites W2150088870 @default.
• W2082316703 cites W2150354188 @default.
• W2082316703 cites W2151845123 @default.
• W2082316703 cites W2153409140 @default.
• W2082316703 cites W2159831861 @default.
• W2082316703 cites W2166806711 @default.
• W2082316703 cites W2167885314 @default.
• W2082316703 cites W2287054275 @default.
• W2082316703 doi "https://doi.org/10.1016/j.meegid.2013.05.013" @default.
• W2082316703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769806" @default.
• W2082316703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23722024" @default.
• W2082316703 hasPublicationYear "2013" @default.
• W2082316703 type Work @default.
• W2082316703 sameAs 2082316703 @default.
• W2082316703 citedByCount "18" @default.
• W2082316703 countsByYear W20823167032014 @default.
• W2082316703 countsByYear W20823167032015 @default.
• W2082316703 countsByYear W20823167032016 @default.
• W2082316703 countsByYear W20823167032017 @default.
• W2082316703 countsByYear W20823167032018 @default.
• W2082316703 countsByYear W20823167032019 @default.
• W2082316703 countsByYear W20823167032020 @default.
• W2082316703 countsByYear W20823167032021 @default.
• W2082316703 countsByYear W20823167032023 @default.
• W2082316703 crossrefType "journal-article" @default.
• W2082316703 hasAuthorship W2082316703A5024940167 @default.
• W2082316703 hasAuthorship W2082316703A5033794499 @default.
• W2082316703 hasAuthorship W2082316703A5050053792 @default.
• W2082316703 hasBestOaLocation W20823167031 @default.
• W2082316703 hasConcept C104317684 @default.
• W2082316703 hasConcept C121608353 @default.
• W2082316703 hasConcept C135763542 @default.
• W2082316703 hasConcept C159047783 @default.
• W2082316703 hasConcept C159654299 @default.
• W2082316703 hasConcept C202878990 @default.
• W2082316703 hasConcept C22070199 @default.
• W2082316703 hasConcept C2522874641 @default.
• W2082316703 hasConcept C2778220009 @default.
• W2082316703 hasConcept C31467283 @default.
• W2082316703 hasConcept C54355233 @default.
• W2082316703 hasConcept C86803240 @default.
• W2082316703 hasConceptScore W2082316703C104317684 @default.
• W2082316703 hasConceptScore W2082316703C121608353 @default.

• next